Heather Jones, MD
University of Pennsylvania Cancer Center
Last Modified: November 5, 2001
Presenter: B. Guix
Presenter's Affiliation: Radiation Oncology, Fundacio IMOR, Barcelona, Spain
Type of Session: Scientific
Keloids form as a result of abnormal growth of scar tissue usually after injury to the skin. The incidence ranges form 3 to 15%. The formation of keloids can result in itching, burning and bleeding. This prospective study analyzes the treatment of keloids by HDR brachytherapy with or without previous surgery.
HDR brachytherapy was a highly effective treatment of keloids. It was well tolerated and no significant side effects were noted. It was preferably to have the keloid completely excised prior to HDR brachytherapy. Brachytherapy was preferable to superficial x-rays or low energy electrons because the more selective deposition of radiation in the tissue, and the less amount of normal tissue irradiated. HDR was preferable to LDR brachytherapy because it can be done in an out-patient basis, its relatively low cost, excellent radiation protection and better dose distribution obtained. This allowed a high local control with no significant HDR brachytherapy related sequelae or complication.
This study indicates that treatment of keloids with HDR results gives good cosmesis and reduces dose to normal tissue, which is paramount in the treatment of non-malignant disease with radiation. The long-term data would also seem to indicate no excessive late effects with the increase in dose.
Oct 11, 2010 - Radical prostatectomy, external-beam radiotherapy, and brachytherapy result in several quality-of-life issues after prostate cancer treatment in patients not receiving adjuvant hormonal treatment, including either improvement in or worsening of urinary irritative-obstructive symptoms in addition to the more commonly discussed sexual and incontinence issues, according to research published online Oct. 4 in the Journal of Clinical Oncology.