Reviewer: Neha Vapiwala, MD
Abramson Cancer Center of the University of Pennsylvania
Last Modified: March 21, 2007
Presenter: Beltran-Gárate, B.
Presenter's Affiliation: Hospital Rebagliati, Peru
Type of Session: Scientific
It has been demonstrated that geographic variations can predict for the clinical behavior and pathologic characteristics of malignant lymphomas. Adult T -cell leukemia/lymphoma (ATLL) is an aggressive lymphoma associated with the human T-cell lymphotropic virus type-I (HTLV-I). This disease is commonly seen among the population of Southern Japan, the Caribbean, and parts of South America, and can have a very heterogeneous manifestation. The Shimoyama system describes four types of ATLL: acute, lymphomatous, chronic, and smoldering. More recently, the authors have described a primary cutaneous subtype in Perú (EHA 2001: abstract 129). The WHO-EORTC has a classification system for lymphomas that provides some assistance in developing a unified nomenclature. The authors initiated this study to establish the relative frequency of cutaneous lymphomas and to examine the clinical relevance of the new WHO/EORTC classification in a “General Hospital” in Lima-Perú
Materials and Methods
In this retrospective analysis, MF is the most frequent type of primary cutaneous lymphoma seen at General Hospital, Peru, and has a relatively favorable overall survival at five years. Although ATLL is the second most common form seen, it is associated with a relatively poor prognosis.
This retrospective, single institution report offers a very interesting perspective of primary and secondary cutaneous lymphoma. By describing the characteristics of a Peruvian patient population, the authors provide an account of the expected distribution and survival outcomes of this relatively rare disease in an endemic population. This information can then potentially serve as a basis for future epidemiologic analyses of both primary and secondary cutaneous lymphomas.
Jun 16, 2010 - Although several single-institution studies have reported an increase in mastectomy rates in the past decade, unilateral mastectomy rates appear to have decreased from 2000 to 2006, according to a population-based analysis published online June 14 in the Journal of Clinical Oncology.