PET Response is the Most Powerful Predictor of Survival after Radical Radiotherapy/Chemoradiotherapy for Unresectable Non-Small Cell Lung Cancer
William Levin, MD
University of Pennsylvania Cancer Center
Last Modified: November 6, 2001
Presenter: M.P. MacManus
Presenter's Affiliation: Peter MacCallum Cancer Institute, East Melbourne, Australia
Type of Session: Scientific
Frequently, clinicians have difficulty interpreting CT scans and MRI's done on patients with cancer, particularly after surgery or radiation therapy. Positron emission tomography (PET) is an imaging technique that measures glucose metabolism in cells. There is evidence that tumor cells have increased uptake and metabolism of these sugar molecules, as compared to non-malignant cells. Fluorodeoxyglucose (FDG)is the radioactive tracer used in this technique. Standard uptake values (SUV) measure the intensity of tracer identified on the PET study. It is generally accepted that higher SUV are more likey to represent malignancy as opposed to scaring or inflamation.
PET-response to radical RT was a more powerful predictor of survival in NSCLC than any of the recognized prognostic factors. CT response was not strongly correlated with survival.
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