University of Pennsylvania Cancer Center
Last Modified: May 19, 1998
While another study presented yesterday demonstrates that older breast cancer patients with early stage breast cancer can tolerate standard adjuvant chemotherapy, this study finds that elderly patients whose breast cancer has spread to the lymph nodes do not appear to be able to tolerate standard chemotherapy as well as younger patients when using the more toxic drug Methotrexate.
This international study evaluating 1,266 elderly women with node-positive breast cancer found that elderly patients experienced increased toxicity with full dose of standard chemotherapy CMF (Cyclophosphamide, Methotrexate, 5-Fluorouracil). In the study, patients under 65 years of age experienced less toxicity than patients between the ages of 65-70. Patients over the age of 70 experience moderate toxicity especially mucosal toxicities (oral, gastrointestinal or vesical) higher than all other age groups. This finding will help physicians tailor oncology care to this patients population, providing as much active treatment as can be tolerated, and selecting the most appropriate active drugs available.
Feb 11, 2010 - Whole-breast irradiation spread over fewer days (accelerated, hypofractionated radiation) following breast-conserving surgery for cancer appears non-inferior to standard radiation treatment, according to research published in the Feb. 11 issue of the New England Journal of Medicine. This adds to a study recently released Online First in The Lancet Oncology, which showed that hypofractionated radiotherapy for breast cancer patients may provide a better quality of life with no evidence of an increase in adverse effects.
Feb 11, 2010
Apr 11, 2011
Aug 1, 2014