IMRT: Another Point of View

S. Jack Wei, MD
Abramson Cancer Center of the University of Pennsylvania
Last Modified: October 22, 2003

Share article

Moderator: Theodore L. Phillips, MD., University of California, San Francisco

Edward C. Halperin, MD, Duke University

  • There is a difference between research and therapy.
  • As a field, we have used research and randomized trials selectively if they show a benefit for radiation, but have dismissed its necessity when we do not have the data.
  • There have been a number of cases where early results from non-randomized data compared to historic controls appeared to show a benefit, but did not show a benefit after randomized testing. Examples include bone marrow transplant for breast cancer, beta-carotene for decreasing cancer incidence, hyperfractionated radiation for pediatric brain stem tumors, etc.
  • Non-randomized data compared to historic controls is not equal to randomized data.
  • The increased treatment time and monitor units due to IMRT result in higher leakage and scatter as is evidenced by the increased rate of second neoplasms with IMRT (1% vs. 1.75% at 10 years).
  • We must not confuse differential dose distributions with differential outcomes.
  • IMRT should be viewed as research, not therapy.

Increased Use of IMRT for Self-Referring Urologists

Oct 24, 2013 - Use of integrated intensity-modulated radiation therapy (IMRT) has increased more among urologists who have acquired ownership of IMRT services versus urologists who do not own such services, according to research published in the Oct. 24 issue of the New England Journal of Medicine.

I Wish You Knew

How cancer patients have changed my life

View More

Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.

OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More