Todd Doyle, MD
OncoLink Assistant Editor
Last Modified: November 1, 1999
Presenter: Bolla M et al
Affiliation: EORTC Radiotherapy Cooperative Group
Traditionally, patients with locally advanced, high risk adenocarcinoma of the prostate have been treated with radiation therapy. However, local control and survival have been somewhat disappointing. This study was initiated to investigate whether concurrent hormonal therapy in addition to radiation therapy could improve outcomes. This is the most recent update of this data since its publication in the New England Journal of Medicine two years ago.
Four hundred fifteen patients with T1/T2 adenocarcinoma of the prostate (grade 3), or T3/T4 (any grade) were stratified for prognostic factors and randomized to receive radiation therapy alone or LHRH agonist plus radiation therapy. Hormones were started on day one of RT and continued for three years. The majority of patients were pathologically staged as N0. The median followup is now 65 months.
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