Effective First Line Therapy of Ovarian Cancer with Cisplatin and Prolonged Topotecan Infusion - A NYGOG/ECOG Study
Ivor Benjamin, MD
OncoLink Assistant Editor
Last Modified: May 20, 2000
Presenter: J. Speyer
Affiliation: Mt. Sinai Sch of Med, NYU Sch of Med, Albert Einstein Sch of Med
Becuase of the known activity of cisplatin and topotecan as second line treatment of ovarian cancer and the favorable results with a Phase II 21-day prolonged infusion of topotecan the authors combined these agents in a first line trial.
Materials and Methods:
- 60 patients entered on study
- Patients with FIGO stage IC or greater epithelial ovarian cancer were included
- Planned regimen was:
- Topotecan 0.4 mg/m2/day as a 21 day continuous infusion
- Cisplatin 75 mg/m2/day on day 1
- First four patients treated with 0.4 mg/m2/day Topotecan had severe heme toxicity, therefore remaining patients treated at 0.3 mg/m2/day
- 56 patients treated with 0.3 mg/m2/days as continuous infusion for 14 days with the same cisplain dose
- Cycles repeated every 28 days
- 37% of patients were unable to complete therapy, of note:
- 8 hematologic toxicity
- 2 neurotoxicity
- 5 patients declined to complete therapy because -- often citing the inconvenience of the indwelling catheter and continuous infusion pump
- Stage I/II disease: 5/5 (100%) were NED
- Stage III/IV disease: 20/51 (46.5%) had CCR, 20/51 (46.5%) had PR, 2 (5%) had stable disease, 1 had progression (2%).
- Overall response rate: 93%
- 5 of 13 patients who underwent second-look surgery had pathological complete responses
- Median time to progression was 14.2 months
- This regimen is highly effective in women with previously untreated epithelial ovarian cancer
- The authors are currently embarking on a trial of prolonged oral topotecan in bid dosing followed by sequential paclitaxel and carboplatin
- Topotecan combined with cisplatin is a promising alternative first line regimen for epithelial ovarian cancer
- This regimen may be an excellent choice for patients with hypersensitivity to taxanes as an alternative to desensitization
- The possible negative impact of a 14-day continuous IV infusion on quality of life in these patients remains to be determined
- The author's subsequent trial with oral topotecan -- if similarly effective -- may gain wider patient acceptance
ASCO: Pazopanib Ups Survival in Advanced Ovarian Cancer
Jun 4, 2013 - For women with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who have undergone surgery and first-line chemotherapy, maintenance therapy with pazopanib is associated with significant longer median progression-free survival versus placebo, according to a study presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.
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