Heather Jones, MD
University of Pennsylvania Cancer Center
Last Modified: November 5, 2001
Presenter: B. Guix
Presenter's Affiliation: Radiation Oncology, Fundacio IMOR, Barcelona, Spain
Type of Session: Scientific
Keloids form as a result of abnormal growth of scar tissue usually after injury to the skin. The incidence ranges form 3 to 15%. The formation of keloids can result in itching, burning and bleeding. This prospective study analyzes the treatment of keloids by HDR brachytherapy with or without previous surgery.
HDR brachytherapy was a highly effective treatment of keloids. It was well tolerated and no significant side effects were noted. It was preferably to have the keloid completely excised prior to HDR brachytherapy. Brachytherapy was preferable to superficial x-rays or low energy electrons because the more selective deposition of radiation in the tissue, and the less amount of normal tissue irradiated. HDR was preferable to LDR brachytherapy because it can be done in an out-patient basis, its relatively low cost, excellent radiation protection and better dose distribution obtained. This allowed a high local control with no significant HDR brachytherapy related sequelae or complication.
This study indicates that treatment of keloids with HDR results gives good cosmesis and reduces dose to normal tissue, which is paramount in the treatment of non-malignant disease with radiation. The long-term data would also seem to indicate no excessive late effects with the increase in dose.
Sep 19, 2014 - Long-term survival may be increased in medium-risk prostate cancer patients who receive short-term androgen deprivation therapy before and during radiation treatment compared with men who receive radiation alone. In addition, proton beam therapy may be associated with a decreased risk of disease recurrence after 10 years and has minimal side effects after one year, according to research presented at the 51st Annual Meeting of the American Society for Radiation Oncology, held from Nov. 1 to 5 in Chicago.