University of Pennsylvania Cancer Center
Last Modified: May 18, 1998
Monoclonal antibodies are small proteins directed against ³marker proteins,² known as antigens, present on the surface of tumor cells. This antibody, known as Anti-B1 Antibody, is directed against CD-20 antigens present on follicular lymphoma cancer cells. Radioactive iodine (I-131) attached to the monoclonal antibody provides directed killing of the cells to which it attaches.
The researchers of this study presented results from a phase II trial of I-131 Anti-B1 Antibody, conducted with patients not previously treated for follicular lymphoma. The results were quite impressive, with an initial tumor response rate of 100 percent -- 71% complete response and 9% partial response -- in 21 patients. Treatment was generally well-tolerated. This therapy appears to be a promising new agent for first-line treatment of follicular lymphoma, though larger trials will be needed to determine its long-term benefit.
Sep 26, 2012 - An initial watch-and-wait strategy does not have a detrimental effect on the freedom from treatment failure or overall survival rate in selected patients with low-tumor burden follicular lymphoma compared with patients initially treated with rituximab-containing regimens, according to research published online Sept. 24 in the Journal of Clinical Oncology.