Presentation, Prognostic Factors and Patterns of Failure in Adult Rhabdomyosarcoma
Presenter: J.H. Simon
Presenter's Affiliation: University of Iowa, Iowa City
Type of Session: Scientific
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood, with about 400 new cases per year. Five year survival rates are around 70%. Unfortunately, adults with rhabdomyosarcoma have a much poorer prognosis. This retrospective study was undertaken to identify the factors responsible for poor outcome.
Materials and Methods
The cases of 39 patients were examined, 26 male and 13 female.
Median age was 45 years.
Multivariate analysis was performed using Cox regression models to determine prognostic factors for overall survival, progression free survival, and local control.
A bimodal age distribution was observed, with the first peak between the late teens-30 years and the second between 60-69 years.
40% had extremity sarcomas.
2/3 of tumors were larger than 5 cm.
Embryonal histology was found in 26 %.
Median survival was 2.25 years with an overall 5-year survival rate of 35 %.
Multivariate analysis identified non-embryonal histology, favorable site, female gender, early T stage, and absence of nodal metastasis as predictors of improved survival.
5 year local control rate was 51 %.
Only early T-stage predicted for better local control.
Overall prognosis of adult rhabdomyosarcoma in adults is worse than reported in children. Age criteria, within the adult population did not further classify outcome. Adult disease is more common in the extemities, while more common in the head and neck region in children.
Generalizations from this study are not easily made, given that this is a small retrospective study from a single institution. Nevertheless, adults with rhabdomyosarcoma appear to fare less well than their pediatric counterparts
Oncolink's ASTRO Coverage made possible by an unrestricted Educational Grant from Bristol-Myers Squibb Oncology and Pharmacia Oncology.