Kevin Fox, MD
Last Modified: June 9, 2002
Dear OncoLink "Ask The Experts,"
Kevin Fox, MD Assistant Director, Clinical Affairs and Associate Professor of Hematology/Oncology at the Abramson Cancer Center of the University of Pennsylvania responds:
Recommending for or against herceptin has nothing to do with the patient age or menopausal status. The recommendations regarding herceptin are based on the biopsy report that specifically evaluates a marker called HER-2/nue. Patients that have over-expression of this marker are candidates for herceptin therapy. It has thus far been used in patients with metastatic breast cancer and high risk locally advanced breast cancer. There are ongoing studies evaluating the best combination of herceptin with chemotherapy and the appropriate timing of administration. The safety and effectiveness of herceptin has not been evaluated in patients as treatment for "early stage" breast cancer. This is part of a current research trial.
Jan 25, 2015 - In women who undergo surgery to treat Stage I to III invasive HER2+ breast cancer, postoperative treatment with concurrent chemotherapy and Herceptin significantly improves disease-free survival, according to research presented at the San Antonio Breast Cancer Symposium, held from Dec. 9 to 13.