Dear OncoLink "Ask The Experts,"
My brother-in-law has been diagnosed with leukemia. Unfortunately, they have been unable to verify which one. They have done two bone marrow biopsies and several chromosome studies but can't conclusively say AML or ALL (although they are leaning toward AML). Is it possible to have both?
Selina M. Luger, MD, Director of the Leukemia Program and Assistant Professor of Medicine at the University of Pennsylvania, responds:
It is sometimes difficult to figure out if leukemia is AML or ALL. Various tests are used to make a definitive diagnosis. However, some acute leukemias don't have features of either and some have features of both. In addition to looking at the cells and doing chromosome studies, we usually also do testing called flow cytometry which may be helpful.
May 2, 2013 - Adult acute myeloid leukemia genomes have an average of 13 mutations, and almost all cases have at least one nonsynonymous mutation in a category of genes relevant for pathogenesis, according to a study published online May 1 in the New England Journal of Medicine.
Feb 15, 2010
Sep 13, 2012