Myeloproliferative disorders

Last Modified: December 1, 2002

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Question

Dear OncoLink "Ask The Experts,"
I have a friend who was just diagnosed with MPD. Could you please send me information on what the disorder is exactly? 

Answer

Selina M. Luger, MD, Director of the Leukemia Program and Assistant Professor of Medicine at the University of Pennsylvania, responds:

MPD means myeloproliferative disorder. In these patients, typically there is an increase in the number of cells being made by the bone marrow resulting in increased blood counts. There can be an increase in the white blood cells, hemoglobin, or platelet counts or a combination of these. Sometimes patients will have enlarged spleens. Depending on the specific manifestations of the patient's disorder as well as the results of additional testing that may be done on the blood or bone marrow, the physician will determine how to treat the patient.


News
ASH: CALR Mutations ID'd in Myeloproliferative Neoplasms

Dec 11, 2013 - Many patients with myeloproliferative neoplasms without mutations in the Janus kinase 2 gene (JAK2) or in the thrombopoietin receptor gene (MPL) have mutations in the CALR gene encoding calreticulin, according to two studies published online Dec. 10 in the New England Journal of Medicine. The research was published to coincide with presentation at the annual meeting of the American Society of Hematology, held from Dec. 7 to 10 in New Orleans.



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