Use of GM-CSF for the treatment of malignant melanoma

Last Modified: May 23, 2004

Share article


Dear OncoLink "Ask The Experts,"
Do you have any current info on the use of GM-CSF for the treatment of malignant melanoma? I would appreciate any help in finding most current info on the effectiveness of this treatment. 


Julia Draznin Maltzman, MD, Attending Physician at the University of Pennsylvania School of Medicine, responds:

The only therapeutic data with GM-CSF for melanoma that I am familiar with is a phase II vaccine trial published in the Journal of Clinical Oncology. 26 patients with advanced melanoma received 6 vaccines of a multi-peptide mixture and an immuno-therapy drug called interleukin-2. These vaccines were prepared with GM-CSF. GM-CSF is a protein found in the blood (secreted by certain types of white blood cells) that helps to regulate the immune response. The thought being that preparing the vaccine with GM-CSF would serve to further rev up the immune system to fight against the melanoma. I am unaware of any data where this protein may be used as monotherapy for melanoma.

You may want to try the OncoLink/EmergingMed clinical trials matching service to see if you are eligible for any clinical trials based at the University of Pennsylvania Cancer Center.

TNF Inhibitors for RA Do Not Increase Malignancy Risk

Sep 13, 2011 - Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors does not increase risk of malignancy, including lymphoma, but it may increase the risk of non-melanoma skin cancer and melanoma, according to a meta-analysis published online Sept. 1 in the Annals of Rheumatic Diseases.

I Wish You Knew

What is Photodynamic Therapy and how is it used in cancer care?

View More

Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.

OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More