Dear OncoLink "Ask The Experts,"
Have you heard of anyone getting a recurrence [of ovarian cancer] despite having normal serum levels of CA-125? In other words, is the following possible: a patient has an elevated CA-125 before initial surgery, goes through treatment and the CA-125 decreases to normal, and then the patient gets a recurrence while the CA-125 stays in the normal range?
Stephen C. Rubin, MD, Professor and Chief of the Division of Gynecologic Oncology, University of Pennsylvania Health System, responds:
CA-125 is usually the earliest indicator of disease recurrence in patients who had an elevated value initially, before treatment. It is therefore very unusual for recurrence to take place in the absence of an increased CA-125, although it can happen occasionally.
Apr 29, 2011 - Women with a history of high-grade cervical intraepithelial neoplasia who have had three consecutive negative cytological smears are at a similar five-year risk of developing cervical cancer or recurrent disease as women in the general population, according to a study published online April 28 in The Lancet Oncology.
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