Last Modified: January 27, 2009
Dear OncoLink "Ask The Experts,"
My mother was diagnosed with endometrial cancer 2 years ago. She had a complete hysterectomy, followed with radiation. Her first Pap smears following this were normal. However, recently, she got an abnormal Pap back. The letter from the doc's office says it was probably due to radiation and another Pap will be done in 6 months. Is this something to be concerned about?
Christina S. Chu, MD, Assistant Professor of the Division of Gynecologic Oncology at the University of Pennsylvania Health System, responds:
It is not uncommon for patients to have irregularities on their Pap tests after radiation therapy, and generally, a follow up Pap is a reasonable approach. If your mother never had abnormal Paps prior to her surgery, it is unlikely that she has developed new vaginal dysplasia (or precancer). Often, the exact wording on the Pap test report is what physicians use to determine their level of suspicion for vaginal precancer, recurrence of endometrial cancer, or just changes due to age and radiation.
Mar 29, 2013 - DNA-based testing with Hybrid Capture 2 assay is more accurate than repeat cytology in identifying women with cervical cancer when their initial Pap smear showed atypical squamous cells of undetermined significance, according to research published online March 28 in The Cochrane Library.