PSA After Prostatectomy

Last Modified: June 10, 2007

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Dear OncoLink "Ask The Experts,"

I had a radical prostatectomy in September 2006. Why would I have anything but a 0.0 PSA at this time? It's very low (PSA=0.08) but I'm not clear as to why ANY exists without a prostate.


David I. Lee, MD, Chief of the Division of Urology at Penn Presbyterian Medical Center, responds:

We aim for a serum PSA that is <0.1 ng/mL. We do not panic when a PSA is still detectable after prostatectomy. There can be benign prostate cells in the pelvis. However, a PSA that steadily climbs into the 0.2 ng/mL range and higher warrants a careful evaluation for the presence of recurrent disease. The adrenal gland can also make a very small amount of PSA.

Findings at meeting cover biomarkers for detecting cancer, measuring PSA after prostatectomy

Oct 1, 2010 - A set of biomarkers may accurately detect prostate cancer, and a method for measuring low levels of prostate-specific antigen in men following radical prostatectomy could help guide treatment, according to two studies presented at the American Association for Cancer Research International Conference on Molecular Diagnostics in Cancer Therapeutic Development, held from Sept. 27 to 30 in Denver.

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