Anti-PSCA antibodies show promise as prostate cancer treatment

Last Modified: November 1, 2001

Share article


Last Updated: 2001-02-20 17:30:38 EST (Reuters Health) - Antibodies against prostate stem-cell antigen (PSCA), a cell-surface antigen overexpressed in prostate cancer tissues, may have therapeutic potential in the treatment of prostate cancer, according to the results of an animal study published online in the February 13th Early Edition of the Proceedings of the National Academy of Sciences.

Dr. Aya Jakobovits, from UroGenesys, Inc. in Santa Monica, California, and colleagues assessed the therapeutic efficacy of two different anti-PSCA antibodies in mice bearing human prostate cancer xenografts.

Both antibodies inhibited subcutaneous and orthotopic xenograft tumors in a dose-dependent fashion, the authors state. In addition, with anti-PSCA therapy, established tumor growth was retarded and distant metastatic disease was inhibited, resulting in significantly prolonged survival.

"Our studies demonstrate a broad antitumor efficacy of anti-PSCA antibodies on initiation and progression of prostate cancer in xenograft mouse models," the researchers conclude. "PSCA is one of the few largely prostate-specific cell-surface antigens that represent potential antibody therapy targets for prostate cancer."

Online Proc Natl Acad Sci USA 2001. February 13, 2001;doc 6246.

See Also:

  • OncoLink: Prostate Cancer


  • News
    Promising results for ancient therapy after prostate cancer treatment

    May 3, 2011 - Acupuncture appears to be quite effective at relieving the hot flashes that are a common side effect of androgen ablation therapy in men with prostate cancer, according to research published in the April 1 issue of the International Journal of Radiation Oncology*Biology*Physics.



    I Wish You Knew

    HPV is now one of the main risk factors for head & neck cancers

    View More



    Blogs and Web Chats

    OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




    OncoLink OncoPilot

    Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

    Learn More