Jill E. Stopfer
Last Modified: November 1, 2001
Dear OncoLink "Ask the Experts,"
I am wondering what the probability is of finding the gene alterations BRCA1 or BRCA2 in a family where:
Jill E. Stopfer, MS Certified Genetic Counselor for the University of Pennsylvania Cancer Risk Evaluation Programs, responds:
There are several issues in calculating the chance of finding a BRCA1 or BRCA2 alteration, also called the "prior probability" of finding a mutation. The only way to determine the prior probability is to take a detailed family history. The family history must include all cancer diagnoses, not just breast and/or ovarian cancer, all ages at diagnosis, and ethnicity. An individualized risk assessment would shed more light on your personal risk. Also, please speak to your doctor about the appropriate screening guidelines for a person with your profile and family history. If you are interested in finding a cancer genetics professional in their areathere is a site within the NCI that can provide that information. Please see The Familial Cancer Risk Counseling & Genetic Testing Information Search Form
The cancer risks associated with a BRCA1 or 2 mutation are usually presented as a range, since different studies have come up with different risk information.
LIFETIME breast and ovarian Cancer risks for BRCA1:
Mar 21, 2014 - Use of the BRCAPRO model for assessment of the likelihood of having a germline BRCA1/BRCA2 mutation, based on age, ethnicity, and family history, may underestimate the risk of mutations, according to a study published online March 17 in the Journal of Clinical Oncology.
Mar 21, 2014
Jul 6, 2011
Jul 30, 2014