Neurological Deficits and Colon Cancer

Richard Whittington, MD
Last Modified: November 1, 2001

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Dear OncoLink "Ask the Experts,"
My mother underwent surgery for colorectal cancer 3 years ago. She was treated with chemotherapy as well as radiation. She did fine until one of her last radiation treatments. At that point, she started having pain in her hips, back and legs. She was diagnosed with a ruptured disk and had additional surgery. The back pain subsided to a degree, but her other symptoms have continued. Can radiation cause this reaction?  

Richard Whittington, MD, Associate Professor of Radiation Oncology at the University of Pennsylvania School of Medicine, responds:

It is not possible to say for certain whether the problem is related to the radiation. The time course is incorrect as this complication usually occurs 6 to 24 months after radiation. Although with higher doses it is possible to occur earlier. Many of her neurological deficits are probably coming from fibrosis in the region of the ruptured disk. This can be caused by surgery and by the ruptured disk, as well as by any bleeding that may have occurred in the region. Radiation would make this fibrosis denser and may exacerbate the problem but would be unlikely to cause the problem.

ASCO: Gastrointestinal Cancer Treatments Analyzed

Feb 27, 2015 - In patients with synchronous stage IV colorectal cancer who receive up-front modern combination chemotherapy, immediate colon surgery to remove the primary tumor is seldom necessary, according to research presented at the annual meeting of the American Society of Clinical Oncology, held from May 29 to June 2 in Orlando, Fla. These findings accompanied several other studies presented at the conference focusing on treatment of gastrointestinal cancers.

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