The Abramson Cancer Center of the University of Pennsylvania
Last Modified: May 8, 2013
My Father-in-law was recently diagnosed with Stage IV Lung cancer. Could you tell me what that means?
Mitchell Machtay, MD, Radiation Oncologist, responds:
The "stage" of a cancer indicates how advanced someone's cancer is. Early stage means that the cancer is relatively small and well confined, while very advanced stage cancer generally means that it has spread throughout the body. Cancer experts have developed "staging systems" for most of the major types of cancer. These classification systems can be very complex and are perhaps overemphasized, but they provide physicians with a form of "medical shorthand" to describe the anatomy and extent of a patient's cancer. Stage is one factor that can be used to estimate prognosis, and it often determines treatment.
In lung cancer, the staging system consists of 4 major categories or stage groupings (Stages I through IV) The 4 major Stage categories of lung cancer are as follows:
Prognosis is best for Stage I. Stage II is also considered to be relatively early lung cancer. Unfortunately, most lung cancer patients are not diagnosed until the cancer has already reached Stage III or IV. The dramatic difference in prognosis between Stage I and stages III/IV has influenced some physicians to screen people who are thought to be at high risk for lung cancer. The hope is that by using screening tests (such as low-dose chest CT scans), lung cancers can be detected at the earliest possible stage when cure is most likely. In some patients, the stage of their cancer is immediately obvious, just based on a 10-minute physical examination. However, in many situations, it is very difficult to determine the correct staging, and this could require complex scans and/or exploratory surgery. For example, many lung cancers that were thought to be stage I based on CT scans and other tests turn out to have stage II or even III disease after surgery is completed. "Under staging" and "over staging" are common problems in oncology and reflect the limitations of current technology.
Proper staging is an important part of caring for a patient with lung cancer. However, stage should absolutely not be the only factor used to determine a treatment plan and to assess prognosis. Many patients with Stage IV disease are excellent candidates for aggressive therapies that can improve both survival time and quality of life. Conversely, some patients with Stage I disease have a very short life expectancy regardless of treatment, often due to conditions other than their lung cancer. Extremely important factors in addition to stage to consider include:
Above all, the most important factor in deciding on a treatment plan should be the patient and his or her family's goals and desires. As said by Abraham Lincoln, "In the end, it's not the years in your life that count. It's the life in your years."
Apr 23, 2013 - For HER2-mutated non-small-cell lung cancer, half of tumors are detected at stage IV, and anti-human epidermal growth factor receptor 2 treatments are associated with encouraging response rates and disease control rates, according to a study published online April 22 in the Journal of Clinical Oncology.
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