Whole brain radiation therapy for CNS lymphoma

Hui-Kuo G. Shu, MD, PhD
Last Modified: September 29, 2002

Share article


Question

Dear OncoLink "Ask The Experts,"

My mother has Primary Central Nervous System (CNS) Lymphoma. After 6 IV methotrexate treatments, her doctor has recommended radiation. What type of radiation procedures do you provide? I assume whole-brain radiation is no longer used?

 

Answer

Hui-Kuo G. Shu, MD, PhD, Assistant Professor in the Department of Radiation Oncology at the University of Pennsylvania, responds:

In fact, whole brain radiation therapy is what is used in cases of CNS lymphoma that has failed IV methotrexate. Quite often, multiple lesions or leptomeningeal spread are seen on imaging studies. Even if only one lesion is seen, the entire brain is at significant risk for recurrence especially in the setting where the lymphoma is apparently failing to respond to the chemotherapy. Overall, whole brain radiation therapy is well tolerated acutely but may have late neurocognitive side effects including a decrease in short term memory and some level of alteration in thinking ability. It is important to remember that neurocognitive side effects will certainly occur eventually in the setting of uncontrolled CNS lymphoma and will most likely be considerably worse than that from the radiation therapy. As always, I recommend that you consult with your physician further regarding potential toxicities of the treatment.



I Wish You Knew

Understanding prostate cancer screening

View More



Blogs and Web Chats

OncoLink Blogs give our readers a chance to react to and comment on key cancer news topics and provides a forum for OncoLink Experts and readers to share opinions and learn from each other.




OncoLink OncoPilot

Facing a new cancer diagnosis or changing the course of your current treatment? Let our cancer nurses help you through!

Learn More