The Abramson Cancer Center of the University of Pennsylvania
Last Modified: May 7, 2013
Why do chemotherapy drugs stop working or need a period of time before they can be used again?
AnswerJames Stevenson, MD, Medical Oncologist, responds:
Cancer cells can find ways to become resistant to chemotherapy through different mechanisms. This is an intensive area of research. Specific resistance mechanisms (such as a gene mutation) can potentially be targeted with a treatment designed to inhibit it. Sometimes resistance is irreversible, but other times we find that the same treatment can be used again with success after a period of time off of that treatment.
This question and answer was part of the OncoLink Brown Bag Chat Series. View the entire Focus on Mesothelioma transcript.
Sep 4, 2014 - For patients with castration-resistant prostate cancer, detection of androgen-receptor splice variant 7 messenger RNA in circulating tumor cells appears to be associated with enzalutamide and abiraterone resistance, according to a study published online Sept. 3 in the New England Journal of Medicine.
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