Carolyn Vachani RN, MSN, AOCN
Last Modified: January 10, 2006
My sister has breast cancer. She has been on a drug called tamoxifen for about 2 years. She recently started bleeding as if having a period. She had a D&C and biopsy and the results showed she now has a tumor with some cancer cells in the uterus. I am curious about the medication: is it associated with cancer of the uterus?
Carolyn Vachani RN, MSN, AOCN, OncoLink's Nurse Educator responds:
Tamoxifen has been linked to an increased risk of endometrial hyperplasia, endometrial polyps, and endometrial cancers. The majority of the endometrial cancers seen in tamoxifen research studies were discovered in early stages and were slow growing, and therefore highly curable. More recently, researchers have noticed an increased risk for a more aggressive endometrial cancer called uterine sarcoma among women who have taken tamoxifen when compared to women who did not take tamoxifen. It also appears that the risk stays with you even after you stop taking the medication, so gynecologic care is important for women who have taken tamoxifen. Despite these risks, experts agree that the benefits of taking tamoxifen outweigh the risks associated with it.
Sep 20, 2013 - Tamoxifen causes central nerve system cell cytotoxicity, and MEK1/2 inhibition can prevent tamoxifen-induced cell death, according to a study published in the Sept. 18 issue of The Journal of Neuroscience.
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