Vaginal Dysplasia

Last Modified: June 18, 2006


Dear OncoLink "Ask The Experts,"

I had a total hysterectomy several years ago. I recently had a Pap smear that returned with HGSIL, yet I do not have a cervix. All of the information I find on the web discusses treatment modalities for cervical HGSIL, but not if located in the vaginal vault. Can you tell me what I can possibly expect for further diagnosis and treatments?


Christina S. Chu, MD, Assistant Professor of the Division of Gynecologic Oncology at the University of Pennsylvania Health System, responds:

Unfortunately, women without a cervix may still suffer from dysplasia of the vagina.

The evaluation is generally the same; high-grade findings on a Pap test require a colposcopic examination of the vulva, with biopsies of abnormal areas. Biopsies verifying the presence of high-grade dysplasia may require treatment. In general, treatment options for vaginal dysplasia include excision (sometimes called upper vaginectomy), laser, or treatment with Effudex (a topical chemotherapy agent).

From the National Cancer Institute