How Family History Effects the Probability of BRCA1 or BRCA2

Jill E. Stopfer
Last Modified: November 1, 2001

Question:

Dear OncoLink "Ask the Experts,"
I am wondering what the probability is of finding the gene alterations BRCA1 or BRCA2 in a family where:
  • only one person in the family is affected by breast cancer or ovarian cancer;
  • two persons in the family are affected by breast cancer or ovarian cancer;
  • only one person in the family is affected both with breast cancer and ovarian cancer?
Also, what is the risk for breast and ovarian cancer in the people you find to be BRCA1 and/or BRCA2 mutation carriers?

Answer:

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