Table of Contents
CancerMail from the National Cancer Institute
UI - 21241460
AU - Yamaguchi M; Ohno T; Miyata E; Toyoda H; Nishii K; Masuya M; Kita K; Shiku H
TI - Analysis of clonal relationship using single-cell polymerase chain reaction in a patient with concomitant mantle cell lymphoma and multiple myeloma.
SO - Int J Hematol 2001 Apr;73(3):383-5
AD - Second Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan. email@example.com
We report a case of concomitant mantle cell lymphoma (MCL) and multiple myeloma (MM) in which we investigated the possibility of a clonal relationship. A 76-year-old man was diagnosed with MCL [immunoglobulin (Ig)M,D-kappa; stage IVB] and MM (IgG-kappa; stage I). Ig heavy chain (IgH) gene complementarity-determining region 3 in DNA from both the MCL tumor and from single MM cells from bone marrow smears was amplified to investigate whether there was a clonal relationship between MCL and MM. Sequence analysis revealed no clonal relationship between MCL and MM in our patient.
UI - 21317173
AU - Yasoshima H; Nakata Y; Ohkubo E; Matsuno Y; Sakurai K; Kubota A; Minagawa K
TI - An autopsy case of pancreatic and ectopic nesidioblastosis.
SO - Pathol Int 2001 May;51(5):376-9
AD - Departments of Surgical Pathology and; Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan. firstname.lastname@example.org
We report an autopsy case of pancreatic and ectopic nesidioblastosis. A five-month-old Japanese girl was born at 35 weeks gestation, and showed clinical symptoms of hyper-insulinemic hypoglycemia before death. At autopsy a tumorous nodule was observed at the portion of the jejunum, 90 cm from Treitz's ligament. The nodule measured 30 x 20 x 20 mm. The ectopic pancreas, also revealed nesidioblastosis histologically. Immunohistologically, both nesidioblastoses were stained positive for chromogranin A, insulin, glucagon and somatostatin. The proliferating cell nuclear antigen (PCNA) and Ki-67 indices were less than 4% in the nesidioblastosis. To our knowledge, this is the first reported case of nesidioblastosis demonstrating proliferating activity with PCNA and Ki-67, and is the third reported case of nesidioblastosis arising in the pancreas and ectopic pancreas.
UI - 21183463
AU - Erko IP
TI - [The transverse colon descending via the small intestine mesentery in rectal cancer]]
SO - Klin Khir 2000 Jun;(6):63-4
UI - 21193610
AU - Lippe P; Berardi R; Latini L; Bracci R; Cellerino R
TI - Severe prognosis of signet-ring cell adenocarcinoma occurring in Meckel's diverticulum.
SO - Ann Oncol 2001 Feb;12(2):277
UI - 21324682
AU - Hwang CS; Chu CC; Chen KC; Chen A
TI - Duodenojejunal intussusception secondary to hamartomatous polyps of duodenum surrounding the ampulla of Vater.
SO - J Pediatr Surg 2001 Jul;36(7):1073-5
AD - Division of Pediatric Surgery, Departments of Surgery and Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Duodenojejunal intussusception is a rare pediatric emergency. A case of duodenojejunal intussusception secondary to hamartomatous polyps of the second portion of duodenum in a 10-month-old boy is reported. Surgical excision of the polyps and reduction of the intussusception were performed. Pathologic examination found hamartomatous polyps. This is the third case report of children in literature, but this is the first case of a child with intussusception surrounding the ampulla of Vater and a successful excision performed without damaging the ampulla of Vater. Copyright 2001 by W.B. Saunders Company.
UI - 21253224
AU - Carolin K; Turfah FH
TI - Multiple small bowel metastasis after laparoscopically assisted abdominoperineal resection.
SO - Surg Endosc 2001 May;15(5):518
AD - Department of Surgery, North Oakland Medical Centers, Pontiac, MI, USA.
Long-term outcome after laparoscopic surgery for colorectal cancer is still unknown. Trocar-site implantation and local recurrence has raised concerns about this new method. We present a case of a laparoscopically assisted abdominoperineal resection (APR) with small bowel recurrence 19 months after the APR. A review of the literature also is presented.
UI - 21404086
AU - Bender GN; Maglinte DD; McLarney JH; Rex D; Kelvin FM
TI - Malignant melanoma: patterns of metastasis to the small bowel, reliability of imaging studies, and clinical relevance.
SO - Am J Gastroenterol 2001 Aug;96(8):2392-400
AD - Radiology-Pathology Division, Armed Forces Institute of Pathology, Washington, DC, USA.
OBJECTIVES: The aims of this study were to determine the frequency of different patterns of melanoma metastases to small bowel on radiological examination, and to assess the reliability of the most commonly used radiological methods for detecting these lesions. METHODS: The records of cases archived as melanoma metastatic to the small bowel of the Armed Forces Institute of Pathology were reviewed. The clinical information, type of imaging procedure performed, and radiological features were analyzed and compared to the findings at surgery and at autopsy. RESULTS: A total of 32 patients had clinical and surgical data with pathological confirmation. Seven patients had metastasis involving the duodenum, 22 had jejunal involvement, and 11 had ileal involvement. Metastases were categorized as polypoid, cavitary, infiltrating, or exoenteric. The polypoid pattern was seen in 20 patients (63%), six of whom showed multiple polypoid lesions (>10), referred to as polyposis. The "target lesion," a discrete polypoid mass with a central ulceration, was observed in only three (9%) of the 32 patients. Eight patients (25%) demonstrated a cavitary pattern, a circumferential mass with inner marginal necrosis, and five (16%) showed an infiltrating pattern. One patient (3%) had an exoenteric lesion with a fistulous tract. The small bowel follow-through demonstrated 32 of 55 metastases (sensitivity 58%). Contrast-enhanced CT demonstrated 32 of 48 masses (sensitivity 66%). Of the six cases of malignant polyposis, none were identified using CT, and only two were diagnosed by small bowel follow-through. CONCLUSIONS: The polypoid pattern, equally distributed between the jejunum and ileum, is the most common manifestation of metastatic melanoma to the small bowel. The target lesion was infrequently seen in this series. Small bowel follow-through and conventional CT seem to be unreliable in demonstrating melanoma metastases to the small bowel.
UI - 21404100
AU - Onuma EK; Amenta PS; Jukkola AF; Mohan V; Borra S; Das KM
TI - A phenotypic change of small intestinal epithelium to colonocytes in small intestinal adenomas and adenocarcinomas.
SO - Am J Gastroenterol 2001 Aug;96(8):2480-5
AD - Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA.
OBJECTIVE: Using a novel monoclonal antibody (mAb Das-1) that specifically reacts with colon epithelium, we examined if there is a phenotypic change of small intestinal enterocytes toward colonocytes in small intestinal neoplastic tissue. METHODS: Tissue sections of the small intestine consisting of adenomas (n = 20, five with histories of familial polyposis), adenocarcinomas (eight primary and one metastatic from colon). carcinoids (n = 2), and hyperplastic polyps (n = 3) were examined by a sensitive immunoperoxidase assay using mAb Das-1 (IgM isotype). Normal jejunal (n = 10) and colonic (n = 10) biopsy specimens were also included as additional controls. RESULTS: mAb Das-1 reacted with normal colonic epithelium but not with jejunal mucosa. However, mAb Das-1 reacted strongly with each of the five adenomas (100%) from patients with histories of familial polyposis, but only five of 15 (33%) of the adenomas from nonfamilial polyposis patients, and each of the eight (100%) adenocarcinomas of the small intestine (p < 0.001). The reactivity with the adenomas from nonfamilial polyposis patients was very focal, whereas in the adenomas with familial polyposis the reactivity was more extensive. Each of the eight carcinomas reacted strongly with mAb Das-1. Adjacent normal small intestinal mucosa did not react. Hyperplastic polyps and the carcinoids did not react with mAb Das-1. CONCLUSION: These data demonstrate a phenotypic change in small intestinal epithelium toward the colonic phenotype, particularly in familial polyposis and in adenocarcinomas. mAb Das-1 may be clinically useful in identifying small intestinal adenomas with "high risk" for malignancy, such as in familial polyposis.
UI - 21404105
AU - Ullerich H; Franzius CH; Domagk D; Seidel M; Sciuk J; Schober; Domschke W
TI - 18F-Fluorodeoxyglucose PET in a patient with primary small bowel lymphoma: the only sensitive method of imaging.
SO - Am J Gastroenterol 2001 Aug;96(8):2497-9
AD - Department of Medicine B, University of Muenster, Germany.
This report describes the case of a patient with primary small bowel lymphoma. Well-established methods of imaging did not give a hint on diagnosis. Increased 18F-fluorodeoxyglucose uptake was visualized on performance of positron emission tomography, corresponding with the intraoperatively found tumorous process. The present case points to a potential superiority of positron emission tomography in visualizing primary small bowel lymphoma.
UI - 21367708
AU - Lee KA; Lee SK; Seo DW; Kim MH
TI - Duodenal metastasis from lung cancer presenting as obstructive jaundice.
SO - Gastrointest Endosc 2001 Aug;54(2):228
AD - University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
UI - 21367722
AU - Yamauchi H; Hirata I; Sasaki S; Egashira Y; Hamamoto N; Murano M; Toshina K; Ueda S; Maemura K; Katsu K
TI - Ileal carcinoid tumor with a rose-shaped appearance by dye spraying: diagnosis at colonoscopy.
SO - Gastrointest Endosc 2001 Aug;54(2):267-8
AD - Second Department of Internal Medicine, the First Department of Pathology, and the Second Department of Anatomy, Osaka Medical College, Takatsuki City, Osaka, Japan.
UI - 21392116
AU - Isomoto H; Ohnita K; Mizuta Y; Maeda T; Onizuka Y; Miyazaki M; Omagari K; Takeshima F; Murase K; Haraguchi M; Murata I; Kohno S
TI - Clinical and endoscopic features of adult T-cell leukemia/lymphoma with duodenal involvement.
SO - J Clin Gastroenterol 2001 Sep;33(3):241-6
AD - Second Department of Internal Medicine, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan. email@example.com
We describe three cases of adult T-cell leukemia/lymphoma (ATLL) with duodenal involvement and provide a review of the literature. The first case, a 74-year-old woman with acute subtype of ATLL, had multiple polypoid lesions from the bulbus extending into the descending portion of the duodenum. The second case, a 70-year-old man with lymphoma subtype of ATLL, had a polypoid tumor in the descending portion of the duodenum and multiple protruded lesions in the small and large intestines. The third case, a 67-year-old man with lymphoma subtype of ATLL, had a flat-elevated lesion in the descending portion of the duodenum, as well as a gastric ulcerated lesion. Biopsies from these lesions showed mucosal invasion of ATLL cells in each case. All patients received combination chemotherapy, which was successful in the first and third cases, accompanied by the disappearance of gastroduodenal lesions.
UI - 21421096
AU - Mainwaring CJ; James CM; Pidgeon F; Webb S
TI - Reactive haemophagocytosis as a consequence of gluten enteropathy-associated intestinal non-Hodgkin's lymphoma with fatal outcome.
SO - Br J Haematol 2001 Aug;114(2):248
AD - Department of Haematology, Royal Hampshire County Hospital, Winchester, UK.
UI - 21426742
AU - Kotanagi H; Kon H; Iida M; Ito M; Koyama K
TI - Adenocarcinoma at the site of ileoanal anastomosis in Crohn's disease: report of a case.
SO - Dis Colon Rectum 2001 Aug;44(8):1210-3
AD - Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
PURPOSE: Proctocolectomy with ileoanal anastomosis has gained acceptance for the treatment of patients with ulcerative colitis. However, there are some patients with Crohn's disease who received ileoanal anastomosis, because some Crohn's colitis is difficult to differentiate from ulcerative colitis. The risk of cancer development at the site of ileoanal anastomosis has not been emphasized in Crohn's disease. METHODS: A 12-year-old patient with Crohn's disease was treated by proctocolectomy with straight ileoanal anastomosis. Twenty-five years after the operation, the patient noticed the tumor that developed at the site of ileoanal anastomosis. RESULTS: This article presents a patient with Crohn's disease who developed invasive adenocarcinoma at the site of ileoanal anastomosis 25 years after proctocolectomy with ileoanal anastomosis. CONCLUSIONS: An ileoanal anastomosis does not eliminate the risk of cancer development, and surveillance after this operation seems advisable.