|Prognostic Value of Immunohistochemically Identifiable Tumor Cells in Lymph Nodes of Patients with Completely Resected Esophageal Cancer|
|Izbicki JR, Hosch SB, Pichlmeier U, Rehders A, Busch C, Niendorf A, Passlick B, Broelsch CE, Pantel K|
|Abramson Cancer Center of the University of Pennsylvania|
| Last Modified: November 1, 2001
Reviewers: Kenneth Blank, M.D. and Leonard Farber, M.D.
Seventeen percent of the 399 lymph nodes which were 'tumor-free' on routine analysis stained positive with the antibody. 15 of the 30 patients who were staged N0 by the usual pathologic methods had positive nodes (N1). The presence of cancer in the lymph nodes found by IHC was predictive of significantly reduced overall survival. Importantly, all patients whose lymph nodes were negative by routine and IHC study were living at last follow-up without evidence of recurrence. The authors conclude that IHC examination of lymph nodes may improve the pathologic staging of esophageal cancer.