|Facile Detection of Mitochondrial DNA Mutations in Tumors and bodily Fluids|
|Makiko S. Fliss, Henning Usadel, Otavia L. Caballero, et al.|
|Abramson Cancer Center of the University of Pennsylvania|
| Last Modified: November 1, 2001
Reviewers: Li Liu, MD
Précis: Bodily fluid testing may detect come cancers
IntroductionAny non-invasive techniques that would aid early detection of cancers would clearly be welcomed. Some studies have demonstrated that high levels of mitochondrial DNA (mtDNA) are ubiquitous in human cells and most copies of mtDNA are identical at birth. Even slight alterations in DNA sequences could have profound effects, including cancer formation. In this study, the researchers evaluated the mtDNA in tumor samples and bodily fluids of cancer patients.
MethodA total of 14 bladder, 13 head and neck, and 14 lung cancer samples were evaluated for mtDNA mutations and the results were compared with mtDNA from patients? bodily fluids.
DiscussionMutated mitochondrial DNA can be found in bodily fluids and may lead to simpler diagnosis of some cancers. Additional investigation in broader patient population is needed before it can be used as a reliable clinical test for cancer diagnosis.