Table of Contents
1
UI - 20567693
AU - Powell KA; Mitchell AM; Manley SW; Mortimer RH; Mortimer RH
TI -
Different transporters for tri-iodothyronine (T(3)) and thyroxine (T(4))
in the human choriocarcinoma cell line, JAR.
SO - J Endocrinol 2000 Dec;167(3):487-92
AD - Conjoint Endocrine Laboratory, Royal Brisbane Hospital Research
Foundation, The Bancroft Centre, 300 Herston Road, Brisbane, Queensland
4029, Australia. kellieP@qimr.edu.au
We investigated transport systems for tri-iodothyronine (T(3)) and
thyroxine (T(4)) in the human choriocarcinoma cell line, JAR, using a
range of structurally similar compounds to determine whether these
thyroid hormones are transported by common or different mechanisms.
Saturable T(3) but not saturable T(4) uptake was inhibited by a wide
range of aromatic compounds (nitrendipine, nifedipine, verapamil,
meclofenamic acid, mefenamic acid, diazepam, phenytoin). Nitrendipine
and diazepam were the most effective inhibitors of saturable thyroid
hormone uptake. Nitrendipine decreased the K(m) for T(4) uptake from a
control value of around 500 nM to around 300 nM (n=6). In contrast, the
K(m) for T(3) uptake was increased from a control value of around 300 nM
to around 750 nM (n=4). Diazepam had similar effects. This divergent
shift in affinity for the uptake of T(3) and T(4) suggested that
separate uptake systems exist for these two thyroid hormones. This
provides evidence for at least two transporters mediating uptake of T(3)
and T(4) in JAR cells: a specific T(4) transporter that does not
interact with T(3) or structurally similar compounds; and a shared
iodothyronine transporter that interacts with T(3), T(4), nitrendipine
and diazepam.
2
UI - 21411924
AU - Moodley M; Moodley J
TI -
Choriocarcinoma and human immunodeficiency virus (HIV) infection: a case
report.
SO - Int J Gynecol Cancer 2001 Jul-Aug;11(4):329-30
AD - MRC/UN Pregnancy Hypertension Research Unit and Department of Obstetrics
and Gynaecology, University of Natal Medical School, Durban, South
Africa.
The appropriate management of gynecological malignancies in human
immunodeficiency virus (HIV)-infected patients is uncertain. Gestational
trophoblastic disease is highly curable and occurs predominantly among
young females. However, such patients are often immunocompromised and
cytotoxic agents may further compromise immunity. This case report
demonstrates the successful management of choriocarcinoma in a
HIV-infected patient.
3
UI - 21329270
AU - Narlawar RS; Shah J; Patkar D
TI -
Images in radiology: complete hydatidiform mole with live pregnancy in a
twin gestation.
SO - J Postgrad Med 2000 Oct-Dec;46(4):291-2
AD - Department Of Radiology, K.E.M. Hospital, Parel, Mumbai, India.
drranjeet@hotmail.com
4
UI - 21420047
AU - Lertkhachonsuk R; Limpongsanurak S
TI -
Serum human chorionic gonadotropin regression pattern in persistent
trophoblastic disease during chemotherapy.
SO - J Med Assoc Thai 2001 Jun;84 Suppl 1():S352-9
AD - Department of Obstetrics and Gynecology, Faculty of Medicine,
Chulalongkorn University, Bangkok, Thailand.
The objective of this study was to identify the regression pattern of
serum beta-hCG in persistent trophoblastic disease patients after
initiating chemotherapy. Eighty-nine women who were diagnosed as
persistent trophoblastic disease in King Chulalongkorn Memorial Hospital
chemotherapy were included. The incidence was 20.2 per cent of total
gestational trophoblastic disease patients. Seventy-two (80.9%) from 89
patients were recruited in our study. Sixty-four (88.9%) patients
responded to first-line chemotherapy and 8 patients (11.1%) resisted.
Suction curettage was done as initial treatment in 61 (84.7%) cases.
Most of them (95.8%) received actinomycin-D as first line treatment.
Total courses of chemotherapy averaged 4 courses, but increased to 8.5
courses in the resistant group. Mean time of serum beta-hCG to remission
was 16.7 and 21.5 weeks in the chemo-sensitive and chemo-resistant
group, respectively. Average time to start chemotherapy was in the tenth
week, and in the resistant group it was started in the sixth week.
Chemotherapy regimen was changed in the fifteenth week. Initial serum
beta-hCG levels were not significantly different between the two groups.
The reduction rates of beta-hCG were significantly different from the
third to the seventh week in the chemo-sensitive and chemo-resistant
groups, which was during the second and third course of chemotherapy
(P<0.05). In conclusion, by using the reduction rate, the regression
pattern of serum beta-hCG level in persistent trophoblastic disease
patients was significantly different between the chemosensitive and
chemoresistant group from the third to the seventh week after starting
chemotherapy.
5
UI - 21426104
AU - Gurlit L; Lampe S; Goeschen K; Krech R; Hartlapp HJ; Bohmer S
TI -
[Typical forms of choriocarcinoma in clinical practice--diagnosis and
therapeutic course in four patients]
SO - Zentralbl Gynakol 2001 Jul;123(7):383-9
AD - Frauenklinik, Klinikum Osnabruck.
The paper reports on four patients with choriocarcinoma. In two of them,
the choriocarcinoma was found after abortion, in one of them following
termination of pregnancy, and in the last patient a hydatidiform mole
was present. In all patients increased beta-HCG was found. One patient
had lung metastasis at the time of diagnosis. In another patient,
choriocarcinoma was suspected owing to ultrasonographic vaginal
examination. According to the Bagshawe Score, 3 patients were low-risk
and were subjected to methotrexate. One patient was medium-risk and
received PEB chemotherapy. All four patients are regarded as cured.
6
UI - 21452205
AU - Rob L; Robova H; Pluta M; Kulovany E; Hrehorcak M; Chmel R; Schlegerova
TI -
D; Kodet R; Macek M
[Regression of hCG in various types of molar pregnancies--clinical
course and prognosis]
SO - Ceska Gynekol 2001 Jul;66(4):230-5
AD - Gynekologicko-porodnicka klinika, onkogynekologicke oddeleni, 2. LF UK
Praha.
OBJECTIVE: To evaluate spontaneous regression curves of hCG serum
positivity in patients with surgically treated molar pregnancies.
Comparison of complete, partial and invasive mole. The study should
result in optimalisation of follow up criteria of molar pregnancies in
respect to their potential malignant change. DESIGN: Retrospective
comparative clinical study. SETTING: Obst. Gyn. Dpt., Oncogynecology
div., 2nd Medical Faculty, FNM, Charles University Prague, Pathology
Dpt., 2nd Medical Faculty, Institute of Biology and Medical Genetics.
METHODS: Evaluation of spontaneous regression curves of serum hCG levels
in 104 molar pregnancies. 46 patients with partial hydatiform mole, 48
patients with complete hydatiform mole, 10 patients with invasive mole.
Serum hCG levels were detected by radioimunoassay (RIA) in the first
period and imunochemoluminisent assay (LIA) in the second period.
Regression curves of hCG positivity in particular moles were
statistically evaluated by Fischer test and t-test. RESULTS: There is
statistically significant difference in spontaneous regression of hCG
positivity in different types of molar pregnancies. Recommended criteria
for gestational trofoblastic disease (GTD) diagnosis and follow up are
fully applicable in clinical practice. There is exception in partial
hydatiform moles, where plateau in hCG regression does not necessarily
implicate chemotherapy in patient with good compliance. CONCLUSION:
Early diagnosis of GTD predominantly due to the widespread use of
ultrasonography changes classical clinical features of molar
pregnancies. Spontaneous regression in hCG positivity in serum is more
rapid in patients with partial hydatiform mole, slower in complete
hydatiform mole and invasive mole. There is no significant change in
malignant potential regarding early detection and treatment.
7
UI - 21423772
AU - Rees HC; Paradinas FJ
TI -
The diagnosis of hydatidiform mole in early tubal ectopic pregnancy.
SO - Histopathology 2001 Sep;39(3):320-1
AD - Charing Cross Department of Histopathology, The Hammersmith Hospitals
NHS Trust, London, UK.
8
UI - 21469903
AU - Lan Z; Hongzhao S; Xiuyu Y; Yang X
TI -
Pregnancy outcomes of patients who conceived within 1 year after
chemotherapy for gestational trophoblastic tumor: a clinical report of
22 patients.
SO - Gynecol Oncol 2001 Oct;83(1):146-8
AD - Department of Ob/Gyn, Peking Union Medical College Hospital, Beijing
100730, China.
OBJECTIVE: The aim of this study was to explore the risk of pregnancy of
patients who conceived within 1 year after successful chemotherapy for
gestational trophoblastic tumor (GTT). METHODS: From 1966 to 1996, 22
patients who conceived within 1 year after chemotherapy were followed up
and analyzed retrospectively. RESULTS: Among 22 patients, 9 had term
deliveries and 1 had a premature birth, 6 had induced abortion at the
patient's request, and 6 had therapeutic abortion because of various
indications such as repeated hydatidiform mole (1 case), intrauterine
death (1 case), inevitable abortion (1 case), and threatened abortion (3
cases). The fetal loss rate was 27.1% (6/22). The incidence rate of
gestational trophoblastic disease (GTD) was 9.1% (2/22). The incidence
rate of GTT was 4.5% (1/22). The average interval between completion of
chemotherapy and pregnancy was 10.25 months in the group of term
pregnancies and 5.86 months in that of fetal loss (P < 0.05), indicating
that the longer the interval, the lesser the risk of GTD. CONCLUSION:
The results suggest that contraception for 1 year is necessary in
patients with GTT after successful chemotherapy. However, in the case of
a patient who conceives within 1 year, it is not necessary to terminate
pregnancy, but the pregnancy must be carefully watched. Copyright 2001
Academic Press.
9
UI - 21469907
AU - Losch A; Lahodny J; Petru E
TI -
Possible influence of granulocyte colony-stimulating factor and
recombinant human erythropoietin on human chorionic gonadotropin
secretion during chemotherapy for choriocarcinoma.
SO - Gynecol Oncol 2001 Oct;83(1):165-6
10
UI - 91147859
AU - Suarez A
TI -
Hydatidiform moles and teratomas confirm the human identity of the
preimplantation embryo.
SO - J Med Philos 1990 Dec;15(6):627-35
AD - Interdisciplinary Study Center, Zurich, Switzerland.
Results of recent research on hydatidiform moles and teratomas show that
during pregnancy the embryo does not receive any message or information
from the mother able to control the mechanisms of development or to
produce the type of cellular differentiation necessary for building the
tissues of the new human adult. Thus, the biological identity of the new
human being does not depend on the sojourn in the uterus; the
preimplantation embryo is the same individual of the human species as
the adult, into whom the embryo can in principle develop.
11
UI - 21477248
AU - Suresh TN; Santosh V; Shastry Kolluri VR; Jayakumar PN; Yasha TC;
TI -
Mahadevan A; Shankar SK
Intracranial haemorrhage resulting from unsuspected choriocarcinoma
metastasis.
SO - Neurol India 2001 Sep;49(3):231-6
AD - Department of Neuropathology, National Institute of Mental Health and
Neurosciences, Bangalore-560 029, India.
A retrospective analysis of clinicopathological data of 10 patients with
clinically unsuspected cerebral metastatic choriocarcinoma was carried
out. All patients were young adult females. History of preceding
pregnancy/abortion was forthcoming in 5 cases but none had a prior
history of abnormal gestation. Features of raised intracranial tension
followed by hemiparesis were the commonest presenting symptoms. A
clinicoradiologic diagnosis of intracerebral haemorrhagic mass, either
primary or secondary to tumour bleed, cortico-venous thrombosis or
arteriovenous malformation, was entertained in 8 out of 10 cases. In
other two cases, ring enhancing lesions prompted the diagnosis of
granulomatous masses. Eight patients were operated upon, of whom two
died after short hospital stay, and were autopsied. All had haemorrhagic
masses noted at surgery/autopsy. Accurate diagnosis of metastatic
choriocarcinoma was established only by histologic examination of these
haemorrhages. This report emphasizes the importance of considering
metastatic choriocarcinoma as an important differential diagnosis of
haemorrhagic intracerebral lesions in women of child bearing age group.
Measurement of serum/CSF level of HCG in suspected cases helps to
implement early therapy. The diagnostic value of histopathologic
examination of surgically resected blood clots in determining aetiology
of intracerebral haemorrhagic masses is highlighted.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.
About OncoLink Contact OncoLink Privacy statement Disclaimer Link to OncoLink Home