UI - 21240496
AU - Sarmiento MA; Neme D; Fornari MC; Bengio RM
Guillain-Barre syndrome following 2-chlorodeoxyadenosine treatment for
Hairy Cell Leukemia.
SO - Leuk Lymphoma 2000 Nov;39(5-6):657-9
AD - Department of Clinica Hematologica, Instituto de Investigaciones
Hematologicas Mariano R. Castex. Academia Nacional de Medicina de Buenos
A 68-year-old man, with Hairy Cell Leukemia developed a Guillain-Barre
syndrome (G-B), 32 days after a single course of 2-Chlorodeoxyadenosine
(CDA) at 0,14 mg/k/d, for five days in a two-hour-i.v. infusion and
following a febrile neutropenia episode. In order to clarify whether
this G-B case was related to an infection or to CDA neurotoxicity, we
screened for infection-related autoimmune G-B and for antibodies (abs.)
against gangliosides of peripheral nerves. Blood and urinary cultures
were negative as well as serum anti-virus abs. However, serum
anti-ganglioside abs. were positive for anti-asialo GM1 and anti-Gd1b.
This latter finding was consistent with an autoimmune mechanism, not
described until now as CDA neurotoxicity. In the present case, we do not
have enough evidence to link CDA administration to the G-B syndrome. We
think that it is necessary to exclude other causes of neurotoxicity
before considering CDA adverse effect.
UI - 21450462
AU - Sambani C; Trafalis DT; Mitsoulis-Mentzikoff C; Poulakidas E;
Makropoulos V; Pantelias GE; Mecucci C
Clonal chromosome rearrangements in hairy cell leukemia: personal
experience and review of literature.
SO - Cancer Genet Cytogenet 2001 Sep;129(2):138-44
AD - Laboratory of Health Physics & Environmental Hygiene, I/NT-RP, NCSR
"Demokritos," 153 10 Aghia Paraskevi, Athens, Greece.
Cytogenetic studies in hairy cell leukemia (HCL) are rare. In the
present report, cytogenetic investigations were performed on marrow
cells obtained from 21 HCL male patients with a mean age of 57 years and
active disease. Karyotypic analysis was successful in 18 of the 21
patients, either at diagnosis or in relapse after treatment with IFNa.
Clonal chromosome abnormalities were detected in eight of 18 cases. The
chromosome most frequently involved in the rearranged karyotypes was
chromosome 14. Results are discussed with respect to 79 abnormal HCL
cases obtained from an extensive review of the literature from 1978 to
UI - 21346282
AU - Muta T; Okamura T; Oshima K; Kikuchi M; Niho Y
[European-American-type hairy cell leukemia without splenomegaly,
treated successfully with deoxycoformycin]
SO - Rinsho Ketsueki 2001 May;42(5):426-31
AD - Department of Internal Medicine, Chihaya Hospital.
A 55-year-old Japanese man was hospitalized on October 5, 1999, because
of high fever. Physical examination revealed neither lymphadenopathy nor
hepato-splenomegaly. Laboratory data on admission showed a white blood
cell count of 1,580/microliter, a hemoglobin level of 9.1 g/dl, and a
platelet count of 113 x 10(3)/microliter. A small percentage of abnormal
mononuclear cells were present in the peripheral blood. A bone marrow
biopsy specimen demonstrated myelofibrosis and diffuse infiltration of
abnormal monoculear cells with a mature B cell phenotype. A bone marrow
aspirate showed 29% abnormal mononuclear cells, which had an indented or
folded nucleus and reticular nuclear chromatin. Moderate to strong
tartarate-resistant acid phosphatase activity was detected in these
cells. Although the cytoplasmic projections were poorly preserved in
specimens stained with May-Giemsa, fresh preparations showed numerous
slender cytoplasmic projections by phase-contrast microscopy. The hairy
cells had the phenotype CD5-, CD10-, CD11c+, CD19+, CD20+, CD25+,
lambda. The patient was diagnosed as having European-American-type hairy
cell leukemia (HCL) without splenomegaly, which is quite rare in Japan.
The value of phase-contrast microscopy for recognition of the hairy
cells was emphasized. The patient was treated successfully with
UI - 21431759
AU - Thaker H; Neilly IJ; Saunders PG; Magee JG; Snow MH; Ong EL
Remember mycobacterial disease in hairy cell leukaemia (HCL).
SO - J Infect 2001 Apr;42(3):213-4
AD - Department of Infection and Tropical Medicine, University of Newcastle
Medical School, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE,
UI - 84300326
AU - Culliton BJ
Patient sues UCLA over patent on cell line.
SO - Science 1984 Sep 28;225(4669):1458
UI - 85012639
AU - Blakeslee S
Patient sues for title to own cells.
SO - Nature 1984 Sep 20-26;311(5983):198
UI - 91131397
AU - Annas GJ
Outrageous fortune: selling other people's cells.
SO - Hastings Cent Rep 1990 Nov-Dec;20(6):36-9
AD - Law, Medicine and Ethics Program, Boston University School of Medicine.
UI - 96084908
AU - Hinnie J; O'Reilly DS
Hypocholesterolaemia in hairy cell leukemia.
SO - BMJ 1995 Nov 25;311(7017):1437-8
UI - 21416548
AU - Fujita H; Koharazawa H; Nishida H; Terada S; Morishita T; Kuroyama Y;
Ohata M; Ishigatsubo Y
[Successful treatment of hairy cell leukemia with pentostatin]
SO - Rinsho Ketsueki 2001 Jul;42(7):537-42
AD - Department of Hematology/Rheumatology, Shizuoka Red Cross Hospital.
A 45-year-old woman was admitted to our hospital in August, 1999.
Laboratory data showed a white blood cell count of 5,050/microliter with
78% abnormal lymphocytes, hemoglobin 6.8 g/dl, platelets 4.8 x
10(4)/microliter, and soluble IL-2 receptor 97,600/ml. The abnormal
cells were characterized by a hairy appearance under phase contrast
microscopy, and showed strong tartrate-resistant acid phosphatase
activity. Immunophenotype analysis revealed that these cells were
positive for CD11c, CD19 and CD25, and negative for CD5. Bone marrow
biopsy showed diffuse proliferation of hairy cells with moderate
myelofibrosis. We diagnosed the patient as having European-American-type
hairy cell leukemia. Pentostatin was administered at a dose of 5 mg/m2
weekly. After twelve doses, the peripheral blood data returned to the
normal range with no hairy cells in the blood or bone marrow, although
slight splenomegaly remained. The patient underwent splenectomy in
December of the same year, and we were unable to find any hairy cells by
histological and immunohistochemical examination. Although most patients
with hairy cell leukemia in Japan have the Japanese variant, and the
European-American type is rare, pentostatin is as effective as it is for
European and American patients.
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