|Dietary Fat, Fat Subtypes, and Breast Cancer in Postmenopausal Women: a Prospective Cohort Study|
|Ellen Velie, Martin Kulldorff, Catherine Schairer, et al|
|Abramson Cancer Center of the University of Pennsylvania|
| Last Modified: November 1, 2001
Reviewers: Li Liu, MD
High intake of total dietary fat has been postulated to increase breast cancer risk on the basis of animal studies, international comparisons, and some other case-control studies. However, some prospective cohort studies have shown different results. In this study, the researchers investigated the association between total dietary fat and fat subtype intake and breast cancer risk in a large, prospective cohort study of postmenopausal women.
Materials and Methods
Completed surveys on dietary habits were collected from 40,022 postmenopausal women who enrolled in a study of screening mammography between 1987 and 1989.
With an average follow-up of 5.3 years:
In this study, no link was found between fat intake and development of breast cancer in postmenopausal women. This finding suggests that reductions in total fat intake during adulthood are unlikely to reduce the risk of breast cancer. A woman's decision about fat intake should be guided primarily by risk of heart disease, which is strongly influenced by the type but not total amount of fat.