Table of Contents
1
UI - 11884882
AU - Lee LC; Howes EL; Bhisitkul RB
TI -
Systemic non-Hodgkin's lymphoma with optic nerve infiltration in a
patient with AIDS.
SO - Retina 2002 Feb;22(1):75-9
AD - Department of Ophthalmology, University of California at San Francisco,
USA.
PURPOSE: To report the clinicopathologic features of a patient with AIDS
and clinically regressed systemic non-Hodgkin's lymphoma who
subsequently developed lymphomatous infiltration of the optic nerve and
occlusion of the central retinal vein in both eyes. METHODS: The eyes of
this patient were examined ophthalmologically and by fluorescein
angiography. The eyes, brain, and body were obtained after death and
studied by light microscopy. RESULTS: Ophthalmic examination and
fluorescein angiography revealed optic nerve swelling and central
retinal vein occlusion first in the left eye and shortly thereafter in
the right eye. Postmortem histopathologic examination showed dense
infiltration of both optic nerves by lymphoma as well as necrotizing
vasculitis involving the retinal vessels near the left optic nerve head.
Examination of the brain revealed lymphomatous involvement in the
paraventricular region with associated necrosis and inflammation. No
bone marrow recurrence or other residual systemic lymphoma was present.
CONCLUSION: This case demonstrates that infiltrative optic neuropathy
may occur as the sole ocular manifestation of disease recurrence in a
patient with systemic non-Hodgkin's lymphoma otherwise thought to be in
clinical remission.
2
UI - 11836885
AU - Chernilo S; Trujillo S; Meneses M; Rios JA; Aguirre JJ
TI -
[Pulmonary involvement due to disseminated non Hodgkin lymphoma in one
patient with AIDS]
SO - Rev Med Chil 2001 Nov;129(11):1315-9
AD - Servicio de Medicina Instituto Nacional del Torax y Servicio de Anatomia
Patologica Hospital del Salvador, Santiago de Chile.
Pulmonary involvement due to disseminated non Hodgkin lymphoma (LNH), is
an unusual cause of lung disease in AIDS patients. We report a 38 years
old male patient, with advanced AIDS, who, in the course of three weeks,
developed cough, dyspnea and fever. The chest X ray film showed diffuse
thickening of the peribronchovascular connective tissue with possible
mediastinal lymph node enlargement. The evolution was unfavorable with
hypoxemia, severe anemia, liver damage and elevated levels of lactic
dehydrogenase. The presumptive initial diagnoses were Pneumocystis
carinii pneumonia, pulmonary tuberculosis with hematogenous
dissemination and Kaposi sarcoma. Definitive diagnosis was made through
a transbronchial biopsy performed the day before his death. The
pathological and inmunohistochemical report demonstrated a highly
aggressive lymphoma (lymphoblastic, B precursor). This finding was
confirmed by autopsy that revealed multiple organ involvement.
3
UI - 11860991
AU - Grassi MA; Lee AG
TI -
Lymphomatous meningitis of the Burkitt type presenting with multiple
cranial neuropathies.
SO - Am J Ophthalmol 2002 Mar;133(3):424-5
AD - Department of Ophthalmology, the University of Iowa Hospitals and
Clinics, Iowa City, Iowa 52246, USA.
PURPOSE: To describe diplopia as the initial manifestation of the
Burkitt lymphoma. DESIGN: Observational case report. METHODS:
Retrospective chart review. RESULTS: A 53-year-old human
immunodeficiency virus (HIV)-positive man presented with a severe
headache associated with binocular diplopia. Flow cytometric analysis of
the cerebrospinal fluid demonstrated a monoclonal B-lymphoid cell
population consistent with the Burkitt lymphoma. CONCLUSION:
Ophthalmologists should be aware that diplopia may be the presenting
manifestation of Burkitt lymphoma in an immunocompromised patient.
4
UI - 11876380
AU - Lee W S; Chan T L; Koh M T; Ariffin W A; Lin H P
TI -
Acquired immunodeficiency syndrome presenting as childhood non-Hodgkin's
lymphoma.
SO - Singapore Med J 2001 Nov;42(11):530-3
AD - Department of Paediatrics, University of Malaya Medical Centre, Kuala
Lumpur Malaysia. leews@ummc.edu.my
Two children with non-Hodgkin's lymphoma (NHL) as the presenting illness
of acquired immunodeficiency syndrome (AIDS) are described. There was a
delay in diagnosing the underlying AIDS in both cases. In the first
case, an 18-month-old boy with stage IV, high-grade,T-cell NHL, the
diagnosis of underlying AIDS was suspected only when he developed
recurrent and profound opportunistic infection during chemotherapy. The
second case, an eight-month-old female infant presented initially with
hepatosplenomegaly and thrombocytopenia of undetermined cause. She had
progressive abdominal distension and swelling of her right eye one year
later due to high grade B-cell NHL. She was later found to be
sero-positive for HIV during pre-chemotherapy screening. As the
prevalence of HIV infection continues to increase, HIV infection should
be considered in the differential diagnoses of childhood
hepatosplenomegaly and thrombocytopenia, and as a possible underlying
cause of childhood cancer, especially NHL.
5
UI - 11910920
AU - Lee CY; Chun K; Shimonishi JJ; Hirata K; Ishimura SM
TI -
Non-Hodgkins lymphoma of the oral cavity associated with HIV infection.
SO - Hawaii Dent J 1994 Jun;25(6):6-7, 10-1
6
UI - 11860669
AU - Vilchez RA; Kozinetz CA; Jorgensen JL; Kroll MH; Butel JS
TI -
AIDS-related systemic non-Hodgkin's lymphoma at a large community
program.
SO - AIDS Res Hum Retroviruses 2002 Mar 1;18(4):237-42
AD - Department of Medicine, Baylor Center for AIDS Research, Baylor College
of Medicine, Houston, Texas 77030, USA. rvilchez@bcm.tmc.edu
The introduction of triple antiretroviral therapy has led to reductions
in opportunistic diseases in HIV-infected patients. However, little is
known of the effect of this therapy on the clinical and pathological
features and the outcome of patients with AIDS-related systemic
non-Hodgkin's lymphoma (NHL). We examined the incidence and clinical
manifestations of HIV-infected patients with systemic NHL at the Harris
County Hospital District and Veterans Affairs Medical Center (Houston,
were diagnosed in 3655 HIV-infected patients. Three groups of patients
diagnosed with systemic NHL were identified according to their history
of antiretroviral therapy: treatment naive (n = 20), dual nucleoside (n
= 22), and triple antiretroviral drug-treated patients (n = 34). The
median duration of antiretroviral therapy before the diagnosis of
systemic NHL in the triple antiretroviral and dual nucleoside treatment
groups was 12 versus 8 months (p < 0.0004). Thirty-five percent of
patients (12 of 34) in the triple treatment group had an HIV RNA viral
load of <400 copies/ml and their median CD4+ cell count was 301
cells/mm(3) (range, 46 to 667 cells/mm(3)) at the time of diagnosis of
systemic NHL. More patients treated with triple antiretroviral therapy
received complete courses of chemotherapy as compared with the other two
groups (p = 0.013). However, the overall survival did not differ
significantly among the three groups of patients. These data suggest
that AIDS-related systemic NHL continues to occur even in patients
treated with triple antiretroviral therapy. In addition, this
opportunistic malignancy is associated with significant mortality.
Therefore, it is necessary to develop a better understanding of the
pathogenesis of this disease.
7
UI - 11917248
AU - Mbulaiteye SM; Biggar RJ; Goedert JJ; Engels EA
TI -
Pleural and peritoneal lymphoma among people with AIDS in the United
States.
SO - J Acquir Immune Defic Syndr 2002 Apr 1;29(4):418-21
AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics,
National Cancer Institute, Rockville, Maryland 20852, USA.
mbulaits@mail.nih.gov
OBJECTIVE: To describe the occurrence and characteristics of pleural and
peritoneal lymphoma in a large cohort of persons with AIDS in 11 regions
in the United States. METHODS: We used AIDS and cancer registries to
identify cases of non-Hodgkin lymphoma (NHL) among 304,439 adults with
AIDS. NHLs were categorized by site codes into pleural/peritoneal
lymphoma and other NHLs. Data on age, sex, HIV exposure category,
histology, history of Kaposi sarcoma (KS), CD4 counts, and survival were
analyzed. RESULTS: Fourteen lymphomas were identified (four within the
pleura, 10 in the peritoneum) representing 0.13% (95% confidence
interval [CI], 0.05-0.20) of 10,510 cases of NHL. Those with
pleural/peritoneal lymphoma were similar to those with other NHLs in age
(median, 43 years), race (79% white, 7% black, 14% Hispanic), and HIV
transmission category (86% homosexual men), but they tended to have a
higher prevalence of prior KS (29% vs. 12%; p =.06). More cases of
pleural/peritoneal lymphoma had immunoblastic histology than did other
NHLs (43% vs. 22%; p =.06). CD4 counts for pleural/peritoneal lymphomas
were also higher than for other NHLs (median 203 vs. 65 cells/mm3; p
=.05), but post-NHL survival was similar (median 7.1 vs. 5.1 months,
respectively; p =.32). CONCLUSIONS: Pleural and peritoneal lymphomas are
a rare subtype of AIDS-associated NHL, occurring with less severe immune
deficiency than for other NHLs. The increased frequency among persons
with prior KS suggests a common etiology, presumably infection with
KS-associated herpesvirus, as found in primary effusion lymphoma.
8
UI - 11714040
AU - Wilks D; Boyd A; Clutterbuck D; Krajeski A
TI -
Clinical and pathological review of HIV-associated lymphoma in
Edinburgh, United Kingdom.
SO - Eur J Clin Microbiol Infect Dis 2001 Sep;20(9):603-8
AD - Regional Infectious Diseases Unit, Western General Hospital, Edinburgh,
Scotland, UK. dp.wilks@virgin.net
The incidence and characteristics of HIV-associated lymphoma among a
cohort of patients infected predominantly through intravenous drug use
are reported. Fifty-one definite cases were identified, occurring in a
total cohort of approximately 1,340 individuals. The rate at which
lymphoma occurred as the AIDS-defining illness did not differ
significantly from that in previously published studies in which there
was a preponderance of men infected through homosexual intercourse, and
it was strikingly similar for all patient groups within this cohort. In
patients diagnosed before death, the median survival was 103 days.
Patients presenting with cerebral lymphoma had more advanced HIV
infection and a shorter survival (median of 49 days compared with 149
days for extracerebral lymphoma). Although there is an apparent excess
of cases (expressed as cases per 1,000 years of follow-up) among
homosexual men, this is likely to be due to confounding factors, and
these sources of possible bias are discussed. These data do not support
the hypothesis that rates differ between different patient groups.
9
UI - 11945206
AU - Inungu J; Melendez MF; Montgomery JP
TI -
SO - AIDS Patient Care STDS 2002 Mar;16(3):107-12
AD - School of Health Sciences, Central Michigan University, Mount Pleasant,
Michigan 48859, USA. Inung1j@cmich.edu
To examine the effect of highly active antiretroviral therapy (HAART) on
the occurrence of primary brain lymphoma (PBL), determine the risk
factors for PBL, and assess the difference in survival between
individuals who did and did not develop PBL, data were analyzed from the
Michigan Adult/Adolescent Spectrum of HIV Disease project (ASD). Among
PBL declined from 5.6 cases per 1000 person-year in the pre-HAART era to
2.1 cases per 1000 person-year in post-HAART era. In the multivariate
analysis, individuals whose CD4 count at entry in ASD was either <50
cells/microL (OR: 5.0) or 50-200 cells/microL (OR: 2.3) were
significantly more likely to develop PBL than those with a CD4 count >/=
200 cells/microL. PBL was a terminal condition in these patients. The
median survival time was consistently shorter among individuals who
developed PBL than those who did not, regardless of their CD4 count at
entry into ASD.
10
UI - 11948473
AU - Tam HK; Zhang ZF; Jacobson LP; Margolick JB; Chmiel JS; Rinaldo C;
TI -
Detels R
Effect of highly active antiretroviral therapy on survival among
HIV-infected men with Kaposi sarcoma or non-Hodgkin lymphoma.
SO - Int J Cancer 2002 Apr 20;98(6):916-22
AD - School of Public Health, University of California, Los Angeles, CA
90095-1772, USA.
The effect of highly active antiretroviral therapy (HAART) on survival
in HIV-infected patients with Kaposi sarcoma (KS) or non-Hodgkin
lymphoma (NHL) is unknown. Our study examines survival after HAART for
these 2 malignancies. Analyses were performed using data from 387
HIV-infected men in the Multicenter AIDS Cohort Study (MACS) after a
diagnosis of either KS or NHL in 1990-99. Potential prognostic factors,
including HAART, were evaluated in univariate analyses using
Kaplan-Meier survival curves and log-rank tests. Multivariate survival
analyses were conducted using Cox's time-dependent proportional hazards
models, adjusting for CD4(+) cell levels at the time of cancer diagnosis
and other covariates. Forty-three of 287 KS patients (15%) and 13 of 100
NHL patients (13%) had been treated with HAART. HAART treatment was
associated with improved survival for KS and NHL patients (log-rank p =
0.0001 for each group). In multivariate analyses, HAART was associated
with an 81% reduced risk of death among KS patients [relative hazard
(RH) 0.19, 95% confidence limits (CL) (0.08, 0.45)], compared to those
not exposed to HAART and an 84% reduced risk [RH 0.16, 95% CL (0.04,
0.64)] among NHL patients. Relative hazards estimates were similar for
those with HAART initiation before and after NHL diagnosis. The use of
HAART prolongs overall survival among HIV-positive men diagnosed with KS
and NHL. HAART appears to be effective in improving survival even when
initiated after the diagnosis of NHL and KS. Copyright 2002 Wiley-Liss,
Inc.
11
UI - 11832678
AU - Vilchez RA; Lednicky JA; Halvorson SJ; White ZS; Kozinetz CA; Butel JS
TI -
Detection of polyomavirus simian virus 40 tumor antigen DNA in
AIDS-related systemic non-Hodgkin lymphoma.
SO - J Acquir Immune Defic Syndr 2002 Feb 1;29(2):109-16
AD - Department of Medicine, Baylor College of Medicine, Houston, Texas
77030, USA. rvilchez@bcm.tmc.edu
Systemic non-Hodgkin lymphoma (S-NHL) is a common malignancy during HIV
infection, and it is hypothesized that infectious agents may be involved
in the etiology. Epstein-Barr virus DNA is found in <40% of patients
with AIDS-related S-NHL, suggesting that other oncogenic viruses, such
as polyomaviruses, may play a role in pathogenesis. We analyzed
AIDS-related S-NHL samples, NHL samples from HIV-negative patients,
peripheral blood leukocytes from HIV-infected and -uninfected patients
without NHL, and lymph nodes without tumors from HIV-infected patients.
Specimens were examined by polymerase chain reaction analysis with use
of primers specific for an N-terminal region of the oncoprotein large
tumor antigen ( T-ag ) gene conserved among all three polyomaviruses
(simian virus 40 [SV40], JC virus, and BK virus). Polyomavirus T-ag DNA
sequences, proven to be SV40-specific, were detected more frequently in
AIDS-related S-NHL samples (6 of 26) than in peripheral blood leukocytes
from HIV-infected patients (6 of 26 vs. 0 of 69; p =.0001), NHL samples
from HIV-negative patients (6 of 26 vs. 0 of 10; p =.09), or lymph nodes
(6 of 26 vs. 0 of 7; p =.16). Sequences of C-terminal T-ag DNA from SV40
were amplified from two AIDS-related S-NHL samples. Epstein-Barr virus
DNA sequences were detected in 38% (10 of 26) AIDS-related S-NHL
samples, 50% (5 of 10) HIV-negative S-NHL samples, and 57% (4 of 7)
lymph nodes. None of the S-NHL samples were positive for both
Epstein-Barr virus DNA and SV40 DNA. Further studies of the possible
role of SV40 in the pathogenesis of S-NHL are warranted.
12
UI - 11872851
AU - Miller RF; Jones EL; Duddy MJ; Shahmanesh M
TI -
Progressive intrathoracic lymphadenopathy: EBV associated non-Hodgkin's
lymphoma.
SO - Sex Transm Infect 2002 Feb;78(1):13-7
AD - Windeyer Institute of Medical Sciences, Royal Free and University
College Medical School, University College London, UK.
A 30 year old man presented with late stage HIV disease and
intrathoracic lymphadenopathy. Histology of a mediastinal biopsy
suggested infective follicular hyperplasia or a peripheral T cell
lymphoma. Subsequently, Epstein-Barr virus (EBV) infection was
demonstrated in lymphocytes in the biopsy. Later, hepatosplenomegaly and
peripheral lymphadenopathy developed. Histology of a cervical lymph node
biopsy showed EBV associated diffuse large B cell (non-Hodgkin's)
lymphoma.
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