Table of Contents
1
UI - 11808180
AU - Takeuchi Y; Nagata K; Yokota T; Handa M; Matsunaga H; Nishio Y; Kusugami
TI -
K
[von Recklinghausen disease associated with intrahepatic
cholangiocarcinoma and ampullary carcinoid]
SO - Nippon Naika Gakkai Zasshi 2001 Dec 10;90(12):2467-9
AD - Department of Internal Medicine, Shizuoka Kousei Hospital, Shizuoka.
2
UI - 11911346
AU - Sato Y; Iwafuchi M; Ueki J; Yoshimura A; Mochizuki T; Motoyama H;
TI -
Sugimura K; Honma T; Narisawa R; Ichida T; Asakura H; Van T
Gastric carcinoid tumors without autoimmune gastritis in Japan: a
relationship with Helicobacter pylori infection.
SO - Dig Dis Sci 2002 Mar;47(3):579-85
AD - Third Department of Internal Medicine, Faculty of Health Science,
Niigata University School of Medicine, Japan.
In Japan, most cases of gastric carcinoid tumor (GCT) are unassociated
with either autoimmune gastritis (AIG) showing type-A chronic atrophic
gastritis (CAG-A) or Zollinger-Ellison syndrome (ZES). However, the
pathogenesis of this tumor remains unknown. Recent studies have
determined that Helicobacter pylori infection induces gastric carcinoid
in Mongolian gerbils and that H. pylori lipopolysaccharide exerts a
mitogenic effect on ECL cells. We examined five patients with
histologically diagnosed GCT, 40 patients with H. pylori-positive
gastric ulcer (Hp+GU), 24 patients with H. pylori-positive duodenal
ulcer (Hp+DU), and 12 patients with AIG showing CAG-A topographically.
We compared the prevalence of H. pylori infection, and the levels of
gastrin and pepsinogen (PG) in the serum of patients with GCT with those
of patients with Hp+GU, or Hp+DU, and AIG. We also investigated the
histological characteristics of the tumor and the gastric corpus mucosa
in the GCT patients. The levels of serum gastrin and PG I and II were
measured using an RIA kit. In all five (100%) patients with GCT, H.
pylori infection was present, without any evidence of AIG or ZES. The
serum levels of gastrin in the GCT patients were higher than those in
either Hp+GU or Hp+DU patients and lower than those in the AIG patients.
In contrast, serum PG I levels and the PG I/II ratio were lower in the
GCT group than in the Hp+GU or Hp+DU groups. Histologically, all GCTs
were ECL cell tumors and peritumoral corporal mucosal atrophy was
observed in four of the five patients with GCT. In conclusions, H.
pylori infection and hypergastrinemia were found in the patients with
GCT without AIG. This finding suggests that H. pylori infection may
induce corporal mucosal atrophy and hypergastrinemia that can produce a
GCT with time.
3
UI - 11925864
AU - Hiroyoshi M; Ogino K; Moritomo H; Kitagawa T; Yamamoto H; Watahiki H;
TI -
Ogawa H; Nagata Y
[A case of gastric carcinoids associated with type A gastritis and
gastric cancer]
SO - Nippon Shokakibyo Gakkai Zasshi 2002 Mar;99(3):270-4
AD - Department of Surgery, Seirei Mikatahara Hospital.
4
UI - 11911297
AU - Nilsson A; Janson E T; Eriksson B; Larsson A
TI -
Levels of angiogenic peptides in sera from patients with carcinoid
tumours during alpha-interferon treatment.
SO - Anticancer Res 2001 Nov-Dec;21(6A):4087-90
AD - Department of Medical Sciences, University Hospital, Uppsala, Sweden.
BACKGROUND: Alpha-interferon, a known inhibitor of angiogenesis and cell
proliferation, is used in the standard treatment of patients with
carcinoid tumors. We studied the levels of two angiogenic peptides (bFGF
and VEGF) in sera from patients with carcinoid tumours before and during
treatment with alpha-interferon. The aim was to investigate if the
antitumoral effect of alpha-interferon in these patients could be at
least in part explained by a reduction in the measured angiogenetic
peptides. PATIENTS AND METHODS: Sera from 29 patients with carcinoid
tumours were collected before and during alpha-interferon treatment and
analyzed using commercially available ELISA-kits. RESULTS: Interferon
alpha treatment did not cause reduction of bFGF and VEGF levels in serum
from patients with carcinoid tumours. In fact there was no correlation
between changes in bFGF or VEGF levels and treatment effect. CONCLUSION:
The action of alpha-interferon does not seem to be mediated by bFGF or
VEGF in patients with carcinoid tumours. If alpha-interferon has an
anti-angiogenic effect in this patient group, it is probably mediated by
angiogenic peptides other than bFGF and VEGF.
5
UI - 11923773
AU - Tang SJ; Jutabha R
TI -
Recurrent hemorrhage caused by ileal carcinoid.
SO - Gastrointest Endosc 2002 Apr;55(4):559
AD - UCLA Center for the Health Sciences, Los Angeles, California, USA.
6
UI - 11979736
AU - Tohdo H; Akagi M; Chikamatsu S; Miura T; Watanabe T; Haruma K; Shimamoto
TI -
F; Yoshida K; Toge T
[A case of multiple gastric carcinoid tumor with type A gastritis
treated by distal gastrectomy]
SO - Nippon Shokakibyo Gakkai Zasshi 2002 Apr;99(4):386-90
AD - Department of Internal Medicine, Hiroshima Prefectual Akitsu Hospital.
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