UI - 11740573
AU - Mikosha AS; Tron'ko ND; Staren'kii DV; Rybakov SI
Isoforms of protein kinase C and their distribution in human adrenal
cortex and tumors.
SO - Bull Exp Biol Med 2001 Sep;132(3):841-3
AD - V. P. Komissarenko Institute of Endocrinology and Metabolism, Academy of
Medical Sciences of Ukraine, Kiev. firstname.lastname@example.org
The cytosol and microsomal fractions of human adrenal cortex contain 3
isoforms of protein kinase C: alpha, zeta, and epsilon. The latter
fraction is present in trace amounts. No isoforms beta1, beta2, gamma
and delta were found in these cell fractions. The distribution of
alpha-isoform between the cytosol and microsomal fraction is determined
by tissue origin: in normal tissue its content differs by no more than
10%, while in most tumors this isoform is translocated into the
microsomal fraction. The distribution of zeta-isoform did not depend on
UI - 11805492
AU - Hershcovici T; Feinmesser M; Steinmetz AP; Hardoff R
Adrenocortical tumor in an adult detected by Ga-67 scintigraphy.
SO - Clin Nucl Med 2002 Jan;27(1):60-1
AD - Department of Internal Medicine A, Rabin Medical Center, Petah Tiqva,
UI - 11942965
AU - Patil KK; Ransley PG; McCullagh M; Malone M; Spitz L
Functioning adrenocortical neoplasms in children.
SO - BJU Int 2002 Apr;89(6):562-5
AD - Great Ormond Street Hospital, University Hospital Lewisham, UK.
OBJECTIVE: To describe the clinical features, treatment and outcome of
functioning adrenocortical tumours in children, and to assess the value
of tumour size as a marker for malignant potential. PATIENTS AND
METHODS: Twenty-one children (mean age at presentation 4.9 years, range
0.6-11; 12 girls and nine boys) who presented with a functioning adrenal
mass over a 29-year period (1972-2000) were assessed.
Clinicopathological features and outcome information were obtained from
a structured review of the case-notes. Before 1980 the diagnosis and
staging was mainly obtained by intravenous pyelography and plain X-ray.
Since 1980, ultrasonography, computed tomography and more recently
magnetic resonance imaging were the methods of choice. RESULTS: The mean
(range) duration of symptoms before diagnosis was 31 (2-108) months. The
symptoms and signs at presentation comprised virilization (18 children),
Cushingoid features (three), precocious puberty (three) and hypertension
(four). Three children had malignant neoplasms, one presented with
metastasis and of the other two, one died from the disease within 6
months, despite adjuvant chemotherapy and radiotherapy. The third girl
is disease-free 11 years after complete excision of the neoplasm.
Eighteen children had a benign neoplasm and all are alive and free of
recurrence. In most of the children surgical extirpation was relatively
simple, blood loss minimal, recovery uneventful and the hospital stay
short (mean 5 days). The virilizing effects of all the neoplasms
gradually resolved after surgery within a median (range) of 27 (6-108)
months. CONCLUSIONS: Functioning adrenocortical neoplasms in children
are rare, with a peak incidence in the first decade, are predominantly
unilateral and more common in girls. Most are benign, but both benign
and malignant lesions can present with virilizing and Cushingoid
features. The malignant neoplasms have an extremely poor prognosis,
especially if excision is incomplete, despite adjuvant chemotherapy and
radiotherapy. Although there is an association between tumour size and
malignancy, this cannot be used as a reliable individual discriminator.
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