Table of Contents
1
UI - 11771049
AU - Dadas B; Uslu B; Cakir B; Ozdogan HC; Calis AB; Turgut S
TI -
Intraoperative management of the thyroid gland in laryngeal cancer
surgery.
SO - J Otolaryngol 2001 Jun;30(3):179-83
AD - Department of Otolaryngology and Head and Neck Surgery, Sisli Etfal
Education and Research Hospital, Istanbul, Turkey.
OBJECTIVE: To determine if it is necessary to perform a
hemithyroidectomy routinely with all total laryngectomies or if it
should be reserved for selected cases. DESIGN: A retrospective analysis
of 215 cases who had been operated on due to laryngeal cancer in our
clinic between 1985 and 1999. SETTING: In only 182 cases,
hemithyroidectomy and isthmectomy were performed together with laryngeal
surgery. Of these, 98% were male. Their ages ranged between 42 and 70
years. The tumour was located in the supraglottic region in 93 (51%) and
in the glottic region in 24 (13%) cases. In 65 cases (36%), the tumour
was transglottic. Twenty cases of transglottic tumours (31%) and 3 cases
of glottic tumours (12.5%) were found to have subglottic extension.
METHODS: Total laryngectomy with unilateral or bilateral neck dissection
and hemithyroidectomy on the tumour side plus isthmectomy were performed
on all patients. On the pathologic specimens, subglottic extension was
measured anteriorly and posteriorly from the free edges of the vocal
cords. The specimens were stained with hematoxylin and eosin and
examined under a light microscope. MAIN OUTCOME MEASURES: With glottic
and transglottic carcinomas, the need for thyroidectomy may be based on
the intraoperative assessment of the thyroid gland. In subglottic
carcinomas, a hemithyroidectomy should routinely be performed. There may
be no need to perform thyroidectomy in all total laryngectomy cases.
RESULTS: The thyroid gland was invaded by squamous cell carcinoma in
only 2 cases (1%). Both of these cases were transglottic tumours staged
as T3 and T4 and had a subglottic extension more than 1 cm. CONCLUSIONS:
We recommend routine hemithyroidectomy and isthmectomy during total
laryngectomy only in cases with subglottic extensions more than 1 cm or
thyroid cartilage invasion with tumour. In the other cases, assessment
of extralaryngeal invasion and thyroid gland invasion by the tumour will
determine whether thyroidectomy should be performed.
2
UI - 11935299
AU - Karamouzis MV; Papadas T; Varakis I; Sotiropoulou-Bonikou G;
TI -
Papavassiliou AG
Induction of the CBP transcriptional co-activator early during laryngeal
carcinogenesis.
SO - J Cancer Res Clin Oncol 2002 Mar;128(3):135-40
AD - Department of Biochemistry, School of Medicine, University of Patras,
Patras, Greece.
PURPOSE: CREB-binding protein (CBP) is a transcriptional "integrator"
that is suspected of contributing to tumorigenesis. This is the first
systematic morphologic study evaluating CBP expression in a large series
of human laryngeal tissues containing normal epithelium, premalignant
lesions (hyperplasia and/or dysplasia), and squamous cell carcinoma.
METHODS: Immunohistochemical methodology was performed on formalin-fixed
paraffin-embedded sections by using a monoclonal anti-CBP antibody. CBP
expression was screened and compared in 156 patients with various
laryngeal histologic entities. RESULTS: Nuclear expression of CBP was
found in 44 out of 91 (48.4%) specimens with normal-appearing epithelium
(46.2% weak and only 2.2% moderate positivity), 92 out of 100 (92%) with
hyperplastic lesions (56% weak, 36% moderate/strong, and only 8% no
positivity), 80 out of 103 (77.7%) with dysplastic lesions (45.6% weak,
32.1% moderate/strong, and 22.3% no positivity), 37 out of 45 (82.2%)
with well-differentiated carcinoma (42.2% weak, 40% moderate/strong, and
17.8% no positivity), 31 out of 43 (72.1%) with moderately
differentiated carcinoma (32.6% weak, 39.5% moderate/strong, and 27.9%
no positivity) and eight out of 12 (66.7%) with poorly differentiated
carcinoma (41.7% weak, 25% moderate/strong, and 33.3% no positivity).
Statistical analysis and correlation of the intensity of nuclear
immunostaining among the various histologic entities revealed
statistically significant results. CONCLUSIONS: Overexpression of CBP is
detected from the very early stages of laryngeal carcinogenesis,
suggesting that CBP may play a role in malignant transformation of
precancerous laryngeal lesions. It is possible that overexpression of
this protein is a prerequisite for the observed p53 upregulation in
premalignant lesions, implying an indirect role of CBP in p53-mediated
tumorigenic potential.
3
UI - 11955735
AU - Paisley S; Warde PR; O'Sullivan B; Waldron J; Gullane PJ; Payne D; Liu
TI -
FF; Bayley A; Ringash J; Cummings BJ
Results of radiotherapy for primary subglottic squamous cell carcinoma.
SO - Int J Radiat Oncol Biol Phys 2002 Apr 1;52(5):1245-50
AD - Department of Radiation Oncology, Princess Margaret Hospital, University
of Toronto, Toronto, Ontario, Canada.
PURPOSE: To retrospectively evaluate the outcome after radical
radiotherapy (RT) and surgical salvage and assess the risk of late
toxicity for patients with primary subglottic squamous cell carcinoma
treated at our center. METHODS AND MATERIALS: Between 1971 and 1996, 43
patients with primary squamous cell carcinoma of the subglottis (35 men,
8 women) were treated with radical RT. All received megavoltage
irradiation, most commonly to a dose of 50-52 Gy in 20 fractions during
4 weeks (39 patients). The median follow-up was 4.2 years. RESULTS:
Local control was achieved with RT alone in 24 (56%) of the 43 patients:
7 of 11 with T1, 8 of 12 with T2, 4 of 8 with T3, and 5 of 12 with T4.
The 5-year actuarial local relapse-free rate was 52%. Subsequent local
control was achieved in 11 of the 13 patients with failed RT and
attempted surgical salvage, for an ultimate local control rate of 81.4%
(35 of 43). The 5-year overall and cause-specific actuarial survival
rate was 50.3% and 66.9%, respectively. No patients developed Grade 3 or
4 late radiation morbidity. CONCLUSION: These data support the use of
primary RT in the treatment of patients with primary squamous cell
carcinoma of the subglottis as an appropriate treatment approach
providing an option for laryngeal conservation.
4
UI - 11977389
AU - Struikmans H; Hordijk GJ; Kal HB
TI -
DNA ploidy of primary and recurrent irradiated laryngeal tumors.
SO - Strahlenther Onkol 2002 Jan;178(1):32-5
AD - Department of Radiotherapy, University Medical Center, Utrecht, The
Netherlands. H.STRUIKMANS@RADCL.RUU.NL
PURPOSE: Radiosensitivity of diploid laryngeal cancers, as compared with
that of aneuploid ones, appears to be increased. However, no conclusive
data exist. If a causal relationship exists, then recurrent laryngeal
cancer after irradiation should predominantly be characterized by
aneuploidy. PATIENTS AND METHODS: To test this hypothesis we compared
ploidy of 24 primarily irradiated laryngeal cancers and their subsequent
recurrences. T and N stages were assessed in accordance with the TNM
classification system of the UICC. With flow cytometry DNA ploidy was
assessed. RESULTS: 1. Ploidy of 16 locally recurrent tumors did not
differ from those of primary tumors, i.e. ten and six recurrences of
diploid and aneuploid primary tumors, respectively, remained unchanged,
2. recurrences of four aneuploid primary tumors showed diploidy, 3.
recurrences of four diploid primary tumors showed aneuploidy.
CONCLUSIONS: The results of our study do not support the hypothesis that
recurrent laryngeal cancer after irradiation of the primary tumor is
characterized by aneuploidy.
5
UI - 11809526
AU - Dong Y; Sui L; Watanabe Y; Sugimoto K; Tokuda M
TI -
Clinical relevance of cyclin B1 overexpression in laryngeal squamous
cell carcinoma.
SO - Cancer Lett 2002 Mar 8;177(1):13-9
AD - Department of Physiology, Kagawa Medical University, 1750-1 Ikenobe,
Miki-cho, Kita-Gun, Kagawa 761-0793, Japan.
Cyclin B1 is a key molecule for G2/M phase transition during the cell
cycle and is overexpressed in various human tumors. However, the
expression status of cyclin B1 in laryngeal squamous cell carcinoma
(LSCC) and its clinical significance remain unknown. We used
immunohistochemical studies to examine the expression of cyclin B1 in
102 patients with LSCC. The results showed that cyclin B1 overexpression
was observed in 40 cases (39.2%) of LSCCs and was significantly
correlated with the tumor site (P=0.031), tumor size (P<0.0001), and
advanced stage (P=0.003). In addition, cyclin B1 overexpression was
associated with patients' overall survival, but not with disease-free
survival using Kaplan-Meier analysis. On multivariate analysis, cyclin
B1 expression was not recognized as an independent prognostic factor.
These findings indicate that cyclin B1 overexpression may be associated
with the malignant biological behavior of LSCC.
6
UI - 11977640
AU - Wang G; Ji W; Pan Z; Guo X
TI -
[Feasibility of University of Washington-Quality of Life questionnaire
for follow up of laryngeal cancer in China]
SO - Zhonghua Zhong Liu Za Zhi 2002 Jan;24(1):53-6
AD - Department of Otorhinolaryngology, First Hospital, China Medical
University, Shenyang 110001, China.
OBJECTIVE: To assess the feasibility of University of Washington Quality
of Life (UW-QOL) questionnaire in laryngeal cancer patients treated by
total or partial laryngectomy and their prognostic factors in China.
METHODS: With UW-QOL questionnaire, a survey was conducted in patients
treated by partial (81, Group A) or total (37, Group B) laryngectomy for
laryngeal cancer. RESULTS: The composite QOL scores of group A (692.34
+/- 127.94) were higher than those of group B (636.35 +/- 139.97), with
a difference statistically significant (P < 0.05). Group A (74.32 +/-
23.82; 80.86 +/- 20.26) was better than group B (40.27 +/- 25.76; 69.59
+/- 27.09) in speech and appearance (P < 0.001; P < 0.05); but group B
(92.57 +/- 13.00) was superior to group A (83.02 +/- 20.47) in pain (P <
0.01). Six factors including stage, operative, modality, complication,
postoperative radiotherapy or chemotherapy, with whom to live, chronic
disease before or after operation were related to postlaryngectomy QOL.
CONCLUSION: Partial laryngectomy is superior to total laryngectomy in
speech, appearance and overall QOL. UW-QOL questionnaire is suitable for
QOL research in laryngeal cancer in China.
7
UI - 11977641
AU - Zhang L; Luan X; Pan X; Xie G; Xu F; Liu D; Lei D
TI -
[Surgical management of supraglottic laryngeal carcinoma in 182 patients
with special emphasis on functional preservation]
SO - Zhonghua Zhong Liu Za Zhi 2002 Jan;24(1):59-61
AD - Department of Otorhinolaryngology, Qilu Hospital, Shandong University,
Jinan 250012, China.
OBJECTIVE: To explore the surgical methods and evaluate the long-term
result of laryngectomy in patients with supraglottic laryngeal cancer.
METHODS: 182 patients with supraglottic laryngeal carcinoma underwent
operation from 1979 to 1999, with stage I 11, stage II 45, stage III 49
and stage IV 77 lesions. The choice of surgical procedure was decided
with the disease condition of the larynx. The surgical procedures
proposed by TD Wang were adhered to as: minor partial laryngectomy 36,
major partial laryngectomy 85, subtotal partial laryngectomy with
laryngoplasty 22 and total laryngectomy 39. RESULTS: The ultimate rate
of larynx preservation was 78.6% (143/182) with 69.8% (88/126) in stage
III and IV diseases. The decannulation rate was 81.8% in cases with
preservation of laryngeal function. The overall 3- and 5-year survival
rates were 82.9% and 67.3%, with 76.88% and 57.4% in the advanced (stage
III and IV) cases who survived with preserved laryngeal function. They
were 82.5% and 67.0% in similar advanced cases who were treated by total
laryngectomy. The difference in the survival rates between these two
groups was not statistically significant. CONCLUSION: It is suggested
that preservation of the laryngeal function be possible for advanced
supraglottic laryngeal carcinoma without compromising the remote
survival rate. To improve the rate of larynx preservation, one should
follow the surgical methods suggested.
8
UI - 11757293
AU - Torchinskii LG; Osipova NA; Vetsheva MS; Sokolov VV; Zhelezkina NV;
TI -
Ivanova LM
[General anesthesia and ventilation of the lungs in endoscopic surgery
of tumors of the larynx, trachea and bronchi]
SO - Anesteziol Reanimatol 2001 Sep-Oct;(5):22-6
Clinical study was carried out during 116 total anesthesias for
endoscopic operations on the larynx, trachea, and bronchi.
Multicomponent total anesthesia was based on fentanyl, calypsol,
diprivane, and dormicum microdoses in combination with local lidocaine
anesthesia of the airways and premedication with nonsteroid
antiinflammatory drugs. Interventions on the larynx and proximal part of
the trachea were carried out with the patients' spontaneous respiration
retained; during interventions on the middle part of the trachea, forced
ventilation of the lungs (FVL) was carried out through an intubation
bronchoscope; and during total anesthesia for operations on the tracheal
bifurcation, high-frequency FVL of the intact lung was carried out.
Stable hemodynamics and gas exchange, hypercapnia, and moderate
respiratory acidosis were observed in patients operated on under both
types of FVL. No serious complications during and immediately after
surgery and anesthesia were observed. Hence, the choice of the method of
total anesthesia and ventilation of the lungs in endoscopic
interventions on the airways depends on the level of lesions and degree
of airway obstruction.
9
UI - 11910427
AU - Moreno AB; Lopes CS
TI -
[Quality of life assessment in laryngectomized patients: a systematic
review]
SO - Cad Saude Publica 2002 Jan-Feb;18(1):81-92
AD - Departamento de Epidemiologia, Instituto de Medicina Social,
Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, 20550-900,
Brasil.
Laryngectomy is the main sequela in patients with cancer of the larynx.
The authors conducted a systematic review to evaluate the relationship
between quality of life and laryngectomy. Ninety-six articles published
in scientific journals were identified, and 35 were selected whose main
focus was laryngectomy and quality of life in laryngectomized patients.
Each article was evaluated by way of systematic review. Evaluation of
the qualitative attributes of articles used the Qualitative Assessment
Questionnaire (QAQ), a validated and tested instrument. Most articles
lacked consistency and methodological rigor in measuring quality of life
among laryngectomized patients. The relationship between quality of life
and laryngectomy also fell far short of the multidimensional approach of
the quality of life construct as suggested by the WHO/QOL (World Health
Organization/Quality of Life) group.
10
UI - 11991580
AU - Thibeault SL; Gray SD; Li W; Ford CN; Smith ME; Davis RK
TI -
Genotypic and phenotypic expression of vocal fold polyps and Reinke's
edema: a preliminary study.
SO - Ann Otol Rhinol Laryngol 2002 Apr;111(4):302-9
AD - Department of Surgery, University of Wisconsin-Madison, USA.
Although a great deal of research exists regarding lamina propria
composition, no report exists that relates gene expression in benign
laryngeal lesions to phenotypic markers. In this study, messenger RNA
profiles for extracellular matrix proteins--procollagen I, collagenase,
elastase, fibronectin, fibromodulin, decorin, hyaluronic acid synthase
2, and hyaluronidase--were completed on 5 polyps and 4 Reinke's edema
specimens. These genotypic profiles were correlated to a
videostroboscopic parameter of mucosal wave stiffness, which was used as
a measurement of phenotypic expression. Polyps, characterized by stiffer
mucosal waves, had higher levels of gene expression, whereas stiffer
mucosal wave scores for Reinke's edema were associated with lower gene
activity levels. This study supports the hypothesis that there is a
relationship between genotypic expression found in polyps and Reinke's
edema and phenotype as defined by a loss of or a decreased mucosal wave.
The study also gives clues as to the proteins responsible for the
phenotype.
11
UI - 11991582
AU - Laccourreye O; Veivers D; Bassot V; Menard M; Brasnu D; Laccourreye H
TI -
Analysis of local recurrence in patients with selected T1-3N0M0 squamous
cell carcinoma of the true vocal cord managed with a platinum-based
chemotherapy-alone regimen for cure.
SO - Ann Otol Rhinol Laryngol 2002 Apr;111(4):315-21; discussion 321-2
AD - Department of Otorhinolaryngology-Head and Neck Surgery, LaEnnec
Hospital, Assistance Publique Hjpitaux de Paris, University of Paris V,
France.
Based on an inception cohort of 35 patients with T1-3N0M0 squamous cell
carcinoma of the true vocal cord who had a complete clinical response
after a platinum-based induction chemotherapy regimen and a minimum of 3
years of follow-up, the current retrospective study documented the
long-term results and consequences of local recurrence following the use
of a platinum-based chemotherapy-alone regimen for cure. During the
years 1985 to 1996, 231 patients with invasive squamous cell carcinoma
of the true vocal cord classified as T1-3N0M0 were managed at our
department with a platinum-based induction chemotherapy regimen. A
complete clinical response was achieved in 77 patients. Thirty-five of
the 77 patients with complete clinical response were managed at our
institution with a platinum-based chemotherapy-alone regimen. The
statistical analysis of data on survival, local control, nodal control,
distant metastasis, and metachronous second primary tumor incidence was
based on the Kaplan-Meier product limit method. Univariate analysis was
performed for potential statistical relation between local recurrence
and various variables. The 3- and 5-year actuarial survival estimates
were 91.4% and 88.6%, respectively. Overall, the causes of death were
intercurrent disease in 6 patients and metachronous second primary tumor
in 4 patients. The 3- and 5-year actuarial local control estimate was
64.8%. No significant statistical relation could be demonstrated between
the incidence for local recurrence and the variables under analysis.
Salvage treatment in patients with local recurrence yielded a 100% local
control rate and laryngeal preservation rate. The 3- and 5-year
actuarial lymph node control estimate was 97.1%. The 3- and 5-year
actuarial estimate for patients with distant metastasis was 0%. The 5-
and 10-year actuarial estimates for patients with metachronous second
primary tumor were 9.7% and 28.1%, respectively. Although local
recurrence was noted in almost a third of patients with complete
clinical response who were managed with a platinum-based
chemotherapy-alone regimen, it did not appear to be detrimental, as none
of the patients who had local recurrence ultimately died from their
disease or lost their larynx.
12
UI - 11990522
AU - Jorgensen K; Godballe C; Hansen O; Bastholt L
TI -
Cancer of the larynx--treatment results after primary radiotherapy with
salvage surgery in a series of 1005 patients.
SO - Acta Oncol 2002;41(1):69-76
AD - ENT Department, Odense University Hospital, Denmark.
karsten.joergensen@ouh.fyns-amt.dk
The aim of this study is to present and discuss the results of initial
radiotherapy with salvage surgery and to compare them with those from
centres where primary surgery is the prevailing principle. The series
comprised 1005 consecutive patients treated during the period 1965-1998.
Salvage surgery was performed if patients had residual tumour or
developed recurrence. Disease-specific survival (DSS) and crude survival
(CS) after 5 years, among 643 patients with glottic carcinomas treated
with curative radiotherapy was 88.6% (SE = 1.3) and 65.3% (SE = 2.0),
respectively. Among T1 glottic carcinomas the locoregional control was
88%, i.e. 88% of patients were cured after radiotherapy alone, and the
DSS was 99% both evaluated after 5 years, i.e. the salvage surgery added
approximately 11% to the survival of T1 glottic patients. Only 4%
(12/312) of T1 glottic patients had laryngectomies. Locoregional control
among T2 glottic cases was 67% and the DSS 88%, but, 18% (41/233) of
patients lost their larynx. The corresponding results among T3 glottic
cases were 30% and 59%, i.e. the organ preservation was close to 50%.
Among patients with supraglottic carcinomas, the two estimates were 440
and 63%, respectively. Compared with our results, recent results
published in the literature after initial laser surgery of T1 glottic
carcinomas indicate that there are only minor differences in DSS and
organ preservation, but it is generally agreed, but not proven, that
voice quality after radiotherapy is better. T2 glottic carcinomas
treated by initial supracricoid partial laryngectomy in a selected
series have yielded very high DSS rates with better organ preservation
than was observed in the present series. As to T3 glottic carcinomas,
initial surgery does not produce better survival rates than those
produced in the present series but our organ preservation is higher. The
treatment of patients with supraglottic carcinoma has benefited from
optimization of radiotherapy during recent decades. The role of initial
laser surgery is as yet undecided.
13
UI - 11941586
AU - He G; Zhao Z; Fu W; Sun X; Xu Z; Sun K
TI -
[Study on the loss of heterozygosity and expression of transglutaminase
3 gene in laryngeal carcinoma]
SO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2002 Apr;19(2):120-3
AD - Department of Medical Genetics, China Medical University, Shenyang,
Liaoning 110001 P. R. China. klsun@mail.cmu.edu.cn
OBJECTIVE: To investigate the role of transglutaminase 3 (TGM3) gene in
laryngeal carcinogenesis. METHODS: The authors detected the deletion
indirectly through loss of heterozygosity (LOH) analysis at DNA level
using 4 STR primers within and near TGM3 gene in 72 cases, and detected
the differential expression of TGM3 gene in 8 cases of paired normal and
cancerous tissue of laryngeal carcinoma by Northern blot. RESULTS: LOH
was found existing in all of the microsatellite loci, and the LOH
frequencies were 25.76%, 20.00%, 38.10% and 18.75% at D20S17, D20S607,
D20S99 and D20S841 respectively; LOH concerning at least one
polymorphism locus accounted for 61.11%. No correlation of clinical
stage, lymph node metastasis and differentiation with the LOH of TGM3
gene was observed, P>0.05. TGM3 gene expressed significantly higher in
normal tissues than in paired cancerous tissues. CONCLUSION: TGM3 gene
might play an important role in laryngeal carcinogenesis and further
researches will be needed to clarify the possible mechanisms.
14
UI - 10543650
AU - Groell R; Willfurth P; Schaffler GJ; Mayer R; Schmidt F; Uggowitzer MM;
TI -
Tillich M; Genser B
Contrast-enhanced spiral CT of the head and neck: comparison of contrast
material injection rates.
SO - AJNR Am J Neuroradiol 1999 Oct;20(9):1732-6
AD - Department of Radiology, University Hospital Graz, Austria.
BACKGROUND AND PURPOSE: Contrast-enhanced spiral CT studies of the head
and neck are performed frequently using contrast material volumes of
approximately 30 g iodine and a scan delay of 30-45 seconds. Because
little is known about the effects of contrast material injection rates
on tissue enhancement, this was prospectively investigated in our study.
METHODS: Ninety-seven patients underwent spiral CT of the head and neck.
Each patient was assigned randomly to one of four groups who received
100 mL of nonionic contrast material (300 mg I/mL) at different
monophasic injection flow rates with 1.5, 2, 3, and 4 mL/s. Scanning
started after a constant delay of 35 seconds. The attenuation of the
carotid artery, jugular vein, and sternocleidomastoid muscle was
measured over time and the attenuation of the submandibular and thyroid
gland was evaluated. Vascular attenuation of at least 150 HU was
considered to be sufficient. RESULTS: The mean scan time was 33+/-5
seconds. The study, using an injection rate of 2 mL/s, showed the
longest time of sufficient overall (arterial and venous) vessel
attenuation (27+/-4 seconds, P< or =.008). The injection flow rate did
not influence significantly muscular attenuation (mean enhancement
during scan time: 9+/-7 HU). The 1.5 mL/s protocol showed the lowest
attenuation values of the submandibular gland (81+/-12 HU) and the
highest attenuation values of the thyroid gland (164+/-22 HU), but the
attenuation of the thyroid gland was not statistically different from
that revealed by the 2 mL/s protocol. CONCLUSION: Using 100 mL of
intravenous contrast material with 300 mg I/mL for spiral CT studies of
the entire head and neck, the optimal injection flow is 2 mL/s, whereas
lower flow rates resulted in insufficient venous enhancement.
15
UI - 11892385
AU - Ashurov ZM; L'vova EA
TI -
[Current aspects of endolaryngeal and endotracheal microsurgery in
children]
SO - Vestn Otorinolaringol 2002;(1):15-7
Achievements of today's laryngeal and tracheal surgery came for the most
part from novel optic techniques and anesthesia. All the operations were
performed with application of the microscope or endoscopic devices. Gas
exchange was provided differently: using volume, injection and high
frequency artificial ventilation of the lungs. An individual approach to
gas exchange technique in respiratory obstruction allowed to avoid
emergency tracheotomy. A laryngeal mask was used in children for air
delivery in fibrotracheobronchoscopy. Removal of tumors, dissection of
laryngeal scars, trachea and bronchi were made by means of ultrasound
and laser equipment. Interventions are considered for each condition.
16
UI - 12014221
AU - Sikorska B; Danilewicz M; Wagrowska-Danilewicz M
TI -
Prognostic significance of CD44v6 and nm23 protein immunoexpression in
laryngeal squamous cell carcinoma.
SO - Pol J Pathol 2002;53(1):17-24
AD - Department of Pathomorphology, Morphometry Division, Medical University,
Lodz.
In several tumours expression of CD44 and nm23 protein has been linked
to tumour progression and metastasis. The aim of this study was to
determine if there is any relationship between CD44v6 and nm23 protein
immunoreactivity in squamous cancer cells and prognosis in patients with
laryngeal carcinoma. The samples of human larynx cancer from patients
with lymph node metastases and without lymph node involvement were
analysed for CD44v6 and nm23 protein expression by immunohistochemistry
using monoclonal antibodies. There was no significant difference in
CD44v6 immunoexpression in cancer cells in patients with and without
metastases. The statistical analysis did not reveal difference in
survival time between patients with high and low CD44v6
immunoreactivity. The expression of nm23 protein in laryngeal cancer in
patients with lymph node metastases was significantly decreased in
comparison with patients without metastases. Analysis of survival
revealed that patients with lower expression of nm23 protein in tumour
tissue had significantly shorter survival than patients with higher nm23
immunoreactivity. The results suggest that nm23 protein immunoreactivity
can be useful in predicting tumour behaviour in laryngeal cancer
patients and indicate a lack of association between CD44v6
immunoexpression and tumour progression in those patients.
17
UI - 11876612
AU - Shenoy AM; Kumar SS; Nanjundappa; Prasad S; Premalatha BS
TI -
Supracricoid laryngectomy with Cricohyoidopexy--a clinico oncological &
functional experience.
SO - Indian J Cancer 2000 Jun-Sep;37(2-3):67-73
AD - Department of Head & Neck Surgery, Kidwai Memorial Institute Of
Oncology, Bangalore, Karnataka.
Supracricoid laryngectomy with Cricohyoidopexy (CHP) is a procedure that
is commonly practiced in France & Canada. Eight such procedures were
carried out at Kidwai Memorial Institute of Oncology, Bangalore during
the period from 1991 through 1996. Four Glottic, 3 transglottic & one
supraglottic cancers were subjected to this procedure. The study
comprised of 7 males & 1 female. The average age was 52 years. Two
procedures were done as salvage procedures for radiotherapy (RT)
failures. The patients have a follow-up ranging from one year to six
years, except for one who died soon after discharge from hospital
secondary to myocardial infarction. Median follow up was four years. The
three year acturial disease free survival was 83%. Six out of 8 (75%)
were decannulated, and physiologic deglutition without aspiration was
established in all patients. Hospital stay ranged from 11 to 62 days
averaging 29 days. The speech was analyzed together with other partial
laryngectomies and was found to be qualitatively worse than speech after
other partial laryngectomy procedures. In addition speech intensity
levels after CHP were lower than in other partial laryngectomy
procedures. The speech however allowed normal social interaction. This
procedure certainly has distinct oncological advantage in encompassing
circumferential horse-shoe lesions with minimal subglottic extension
which in the past would have received total laryngectomy and needs to be
included in the repertoire of speech restorative surgery in laryngeal
cancers.
18
UI - 11993723
AU - Albino L; Polo MP; de Bravo MG; de Alaniz MJ
TI -
Uptake and metabolic conversion of saturated and unsaturated fatty acids
in Hep2 human larynx tumor cells.
SO - Prostaglandins Leukot Essent Fatty Acids 2001 Nov-Dec;65(5-6):295-300
AD - Instituto de Investigaciones Bioquimicas de La Plata (INIBIOLP),
CONICET-UNLP, Facultad de Ciencias Medicas, Argentina.
Research on fatty acid metabolism in cultured human larynx tumor cells
Hep2 was carried out.The cells were incubated with either a saturated
(palmitic) or a polyunsaturated (linoleic, alpha-linolenic and
eicosatrienoic (n-6)) radioactive fatty acid (0.66 pM, 24 h). The best
incorporation capacity was observed in the linoleic acid followed by
alpha-linolenic, palmitic and eicosatrienoic acids. All fatty acids
tested were anabolized to higher derivatives within their own family.
Palmitic acid was primarily monodesaturated rather than elongated,
proving to have a very active A9 desaturase activity.With respect to
polyunsaturated acid metabolism, the conversion of alpha-linolenic acid
to higher homologs, although better than linoleic acid, occurred far
less efficiently than that observed in other non-highly undifferentiated
human tumor cells. This impairment in higher polyunsaturated fatty acid
biosynthesis, reflected in the low levels of arachidonic acid in the
fatty acid composition, would not reside in the A5 desaturation step
since Hep2 cells can readily convert eicosatrienoic acid into
arachidonic acid. Considering the potential regulatory role of specific
polyunsaturated fatty acids in the cell proliferative control, the
knowledge of the metabolism of fatty acids in this human tumor cell
would be important for designing future experiments in order to clarify
the mechanism involved in balance, proliferation and cell death.
19
UI - 12018330
AU - Suoglu Y; Erdamar B; Katircioglu OS; Karatay MC; Sunay T
TI -
Extracapsular spread in ipsilateral neck and contralateral neck
metastases in laryngeal cancer.
SO - Ann Otol Rhinol Laryngol 2002 May;111(5 Pt 1):447-54
AD - Department of Otorhinolaryngology, Istanbul School of Medicine, Istanbul
University, Turkey.
We investigated the incidence of extracapsular spread (ECS) and the
impact of ECS on contralateral neck metastasis in 67 patients with
ipsilateral nodal metastasis (IpN+) whose records were extracted
retrospectively from those of 155 laryngeal cancer patients. The
incidence of ECS in association with variables was determined: T stage,
N stage, tumor location, tumor extension, number of positive nodes, and
contralateral neck status. The variables were evaluated to identify
their impact on the rates of contralateral neck metastasis (CNM) and
3-year survival. Of the 67 patients, 30 (44.7%) had ECS. A significant
relationship was found between ECS positivity and increased N stage,
tumor extension up to the midline, number of positive nodes, and CNM (p
= .04, p = .0001, p = .018, p = .0001, respectively). Multivariate
analysis revealed that N stage (p = .002; odds ratio, 3.5517) and the
presence of ECS (p = .0036; odds ratio, 7.7840) in IpN+ were associated
with the greatest risk of CNM. The 3-year survival rate of patients with
ipsilateral ECS was significantly lower than that of patients without
ECS (43% versus 81%, p = .0002). Both CNM and presence of ECS in IpN+
emerged as significant independent predictors for survival with Cox
multivariate analysis (p = .0086 and p = .0234, respectively). This
result indicates the necessity of treating the contralateral N0 neck in
cases of IpN+ with ECS.
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