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UI - 11950848
AU - de Jong MM; Nolte IM; te Meerman GJ; van der Graaf WT; Oosterwijk JC;
TI -
Kleibeuker JH; Schaapveld M; de Vries EG
Genes other than BRCA1 and BRCA2 involved in breast cancer
susceptibility.
SO - J Med Genet 2002 Apr;39(4):225-42
AD - Department of Medical Oncology, University Hospital, Groningen, The
Netherlands.
This review focuses on genes other than the high penetrance genes BRCA1
and BRCA2 that are involved in breast cancer susceptibility. The goal of
this review is the discovery of polymorphisms that are either associated
with breast cancer or that are in strong linkage disequilibrium with
breast cancer causing variants. An association with breast cancer at a
5% significance level was found for 13 polymorphisms in 10 genes
described in more than one breast cancer study. Our data will help focus
on the further analysis of genetic polymorphisms in populations of
appropriate size, and especially on the combinations of such
polymorphisms. This will facilitate determination of population
attributable risks, understanding of gene-gene interactions, and
improving estimates of genetic cancer risks.
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