Table of Contents
1
UI - 11579679
AU - Tomita T
TI -
Immunocytochemical localization of prohormone convertase 1/3 and 2 in
gastrointestinal carcinoids.
SO - Endocr Pathol 2001 Summer;12(2):137-45
AD - Department of Pathology and Laboratory Medicine, University of Kansas
Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
Gastrointestinal carcinoids are derived from the diffuse intestinal
endocrine system and may produce amines and many peptides, including
serotonin, chromogranin A (CGA), and tachykinins. Most peptide hormones
are synthesized as bigger prohormones, which are processed to smaller
active hormones by prohormone convertases (PCs). A total of 35 cases of
gastrointestinal carcinoids, including gastric, duodenal, small
intestinal, appendiceal, and large intestinal carcinoids, were
immunocytochemically stained for serotonin, CGA, and PC 1/3 and 2, in
order to colocalize CGA and PCs in the carcinoids. All carcinoids were
positive for CGA and PCs. Carcinoids that stained strongly for CGA were
generally weakly stained for PCs and those weakly staining for CGA were
more strongly stained for PCs in the majority of the small and large
intestinal tumors. Gastrointestinal carcinoids were positive for CGA and
PCs, and the presence of PCs may suggest that the conversion of peptide
prohormones to smaller peptide hormones occurs in gastrointestinal
carcinoids. PCs immunocytochemistry may be added as a new phenotypic
characterization for gastrointestinal carcinoids.
2
UI - 11761822
AU - Murawa D; Nowakowski W; Murawa P
TI -
[Cases of carcinoid tumor in stomach and retroperitoneal space]
SO - Pol Merkuriusz Lek 2001 Sep;11(63):252-3
AD - I Oddzial Chirurgii Onkologicznej Wielkopolskiego Centrum Onkologii w
Poznaniu.
Authors present two cases of carcinoid localized in stomach and
retroperitoneal space. Diagnosis was based on clinical examination,
endoscopy, CT and histopathological evaluation. The case of gastric
carcinoid was an early lesion (penetrated only mucose and submucose
layer of gastric wall). In opposition, second patient had inoperable
large tumor localized in retroperitoneal space with multiple metastases
to the liver.
3
UI - 9383343
AU - Ahlman H
TI -
Gut neuroendocrine tumours.
SO - Wiad Lek 1997;50 Suppl 1 Pt 1():4-9
AD - Department of Surgery, Sahlgrenska University Hospital.
4
UI - 11786770
AU - Tichansky DS; Cagir B; Borrazzo E; Topham A; Palazzo J; Weaver EJ; Lange
TI -
A; Fry RD
Risk of second cancers in patients with colorectal carcinoids.
SO - Dis Colon Rectum 2002 Jan;45(1):91-7
AD - Department of Surgery, Thomas Jefferson University Hospital and
Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.
INTRODUCTION: It is often stated that patients with colorectal carcinoid
tumors have an increased risk of developing other malignancies. However,
this risk has not been conclusively documented. A comprehensive
evaluation is needed to more thoroughly assess the risk of second
cancers in patients with colorectal carcinoids. METHODS: A search of the
National Cancer Institute Surveillance, Epidemiology, and End Result
database from 1973 to 1996 revealed 2,086 patients with colorectal
carcinoids. This subset of patients was examined for occurrence of
second cancers. The observed incidence of cancer for each site was
compared with the expected incidence based on the gender-adjusted and
age-adjusted cancer rates in the remaining Surveillance, Epidemiology,
and End Result file. A Poisson distribution probability was used to
determine the significance of these comparisons. RESULTS: Patients with
colorectal carcinoids had an increased rate of cancer in the colon and
rectum (P < 0.001), small bowel (P < 0.001), esophagus/stomach (P =
0.02), lung/bronchus (P < 0.001), urinary tract (P = 0.005), and
prostate (P < 0.001), when compared with a control population. Most of
the gastrointestinal tract cancers were synchronous cancers, whereas
lesions outside the gastrointestinal tract were most commonly
metachronous tumors. CONCLUSIONS: A significantly increased risk of
synchronous colorectal, small-bowel, gastric, and esophageal cancers and
metachronous lung, prostate, and urinary tract neoplasms is clearly
demonstrated. After the diagnosis of colorectal carcinoid tumors,
patients should undergo appropriate screening and surveillance for
cancer at these sites.
5
UI - 11835243
AU - Assadi M; Kubiak R; Kaiser G
TI -
Appendiceal carcinoid tumors in children: does size matter?
SO - Med Pediatr Oncol 2002 Jan;38(1):65-6
AD - Department of Pediatric Surgery, University Children's Hospital
Berne-Inselspital, CH-3010 Berne, Switzerland.
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