Table of Contents
1
UI - 11773950
AU - Bourgeois JM; Radhi J; Elden L; Gill G
TI -
Plexiform neurofibroma of the submandibular salivary gland in a child.
SO - Can J Gastroenterol 2001 Dec;15(12):835-7
AD - McMaster University, Hamilton, Canada.
Plexiform neurofibromas in major salivary glands are rarely described.
In the literature, most reported tumours have been present in the
parotid gland region. A three-year-old boy with a family history of
neurofibromatosis presented with a rapidly growing left submandibular
mass. The clinical diagnosis was that of a neurofibroma rather than a
primary salivary gland tumour. Resection of the lesion revealed a
plexiform neurofibroma involving the submandibular gland. Although these
tumours have a neurogenic rather than a salivary gland origin, they must
be considered in the differential diagnosis of a salivary gland lesion
in a patient with a history of neurofibromatosis.
2
UI - 9892871
AU - Rinaldo A; McLaren KM; Boccato P; Maran AG
TI -
Hyalinizing clear cell carcinoma of the oral cavity and of the parotid
gland.
SO - ORL J Otorhinolaryngol Relat Spec 1999 Jan-Feb;61(1):48-51
AD - Department of Otolaryngology, City Hospital, Royal Infirmary of
Edinburgh, UK.
Hyalinizing clear cell carcinoma (HCCC) is a rare, recently described
tumor of salivary gland origin. Differential diagnosis includes benign
lesions as clear cell change in a pleomorphic adenoma or in oncocytoma
and malignant tumors - i.e. epithelial-myoepithelial carcinoma,
polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, clear
cell acinic carcinoma, clear cell squamous carcinoma, clear cell
malignant melanoma, clear cell odontogenic carcinoma, clear cell
rhabdomyosarcoma, sebaceous carcinoma and metastasis of renal carcinoma.
A favorable prognosis after wide local excision has been evidenced.
Three new cases of HCCC (2 in the oral cavity and 1 in the parotid
gland) are presented.
3
UI - 11244374
AU - Boccato P; Rinaldo A; McLaren KM
TI -
A rare tumor of salivary gland origin: hyalinizing clear cell carcinoma.
SO - ORL J Otorhinolaryngol Relat Spec 2001 Mar-Apr;63(2):119-20
4
UI - 11802017
AU - Klenoff JR; Lowlicht RA; Lesnik T; Sasaki CT
TI -
Mandibular and temporomandibular joint arthropathy in the differential
diagnosis of the parotid mass.
SO - Laryngoscope 2001 Dec;111(12):2162-5
AD - Section of Otolaryngology, Yale University School of Medicine, New
Haven, Connecticut, USA.
OBJECTIVE: To increase awareness of temporomandibular joint and
mandibular disease in the overall evaluation and diagnosis of the
parotid mass. STUDY DESIGN: We describe clinical presentations of
pigmented villonodular synovitis and synovial chondrocalcinosis of the
temporomandibular joint, as well as osteoma of the mandible, as they may
initially suggest primary neoplasms of the parotid gland. CONCLUSIONS:
Preauricular swelling is a common presenting symptom for patients
visiting an otolaryngologist. Often this symptom is suggestive of a
parotid mass. However, lesions of the temporomandibular joint and
mandible may also present in this fashion.
5
UI - 11802025
AU - Stennert E; Guntinas-Lichius O; Klussmann JP; Arnold G
TI -
Histopathology of pleomorphic adenoma in the parotid gland: a
prospective unselected series of 100 cases.
SO - Laryngoscope 2001 Dec;111(12):2195-200
AD - Department of Otorhinolaryngology, University of Cologne, Koeln,
Germany. aih06@uni-koeln.de
OBJECTIVES/HYPOTHESIS: Histopathological characteristics of pleomorphic
adenomas, especially of capsular alterations such as thin capsule areas,
capsule-free regions, capsule penetration, satellite nodules, and
pseudopodia in the different subtypes, are described. STUDY DESIGN:
Prospective unselected series of 100 consecutive cases from 1997 to
2000. METHODS: Light microscopic examination and semiquantitative
analysis of the pleomorphic adenomas. RESULTS: Fifty-one (51%)
pleomorphic adenomas were classified as myxoid (stroma-rich) type, 35
(35%) specimens as cellular type, and 14 (14%) as classic subtype.
Ninety-seven percent of all tumors showed areas with thin (<20 microm)
capsule independent of the tumor subtype. Tumors of myxoid subtype
showed the absolute greatest regions of a thin capsule. Especially,
tumors of myxoid type (71%) often had a distinct focal absence of
encapsulation with tumor merging into normal parotid gland tissue; 11%
of the cellular subtype and 43% of the classic subtype presented
capsule-free areas. Thirty-three percent of the myxoid pleomorphic
adenomas, 23% of the cellular subtype, and 21% of the classic subtype
had satellite nodules or pseudopodia. CONCLUSIONS: Almost all
pleomorphic adenomas have focally thin capsules. One-fourth of all
pleomorphic adenomas contain abnormalities such as satellite nodules or
pseudopodia. More than two-thirds of pleomorphic adenomas of the myxoid
(stroma-rich) subtype and at least half of all tumors show a focal
absence of the capsule. Therefore, enucleation or local dissection of
the pleomorphic adenoma is not a sufficient surgical treatment of this
special tumor entity. We recommend, depending on the location of the
tumor, a lateral or total parotidectomy as the treatment of choice.
6
UI - 11755829
AU - Felix A; Rosa-Santos J; Mendonca ME; Torrinha F; Soares J
TI -
Intracapsular carcinoma ex pleomorphic adenoma. Report of a case with
unusual metastatic behaviour.
SO - Oral Oncol 2002 Jan;38(1):107-10
AD - Departamento de Patologia Morfologica, Instituto Portugues de Oncologia
de Francisco Gentil, Rua Professor Lima Basto, 1090-023 Lisboa,
Portugal. anafpinto@mail.telepac.pt
Intracapsular carcinomas ex pleomorphic adenoma are exceedingly rare
salivary glands tumours, known to have a benign clinical behaviour with
metastatic unrecognised potential. We report a case of a 57-year-old
female patient presenting with a typical example of intracapsular
carcinoma ex pleomorphic adenoma of the parotid gland and evidence of
ipsilateral cervical lymph node metastases two years before. The
behaviour of this unique case illustrates the disputed malignancy of
carcinomas arising within encapsulated pleomorphic adenomas.
7
UI - 11755819
AU - Maiorano E; Lo Muzio L; Favia G; Piattelli A
TI -
Warthin's tumour: a study of 78 cases with emphasis on bilaterality,
multifocality and association with other malignancies.
SO - Oral Oncol 2002 Jan;38(1):35-40
AD - Department of Pathological Anatomy and Genetics, Section of Pathological
Anatomy, University of Bari, Policlinico, Piazza G Cesare 11, 70124
Bari, Italy. emaiorano@anatopat.uniba.it
The authors reviewed the clinical records and the histopathological
preparations of 78 cases of Warthin's tumours (WTs), treated at the
Department of Dental Sciences, Centre for the Study of Oral Tumours, of
the University of Bari. All the surgical specimens had been fixed in
neutral buffered formalin, sampled according to the step-serial,
whole-specimen sectioning technique, embedded in paraffin and stained
with haematoxylin-eosin, periodic acid Schiff and Gomori's reticulin.
The results showed that Warthin's tumours characteristically affect the
parotid gland, and most frequently arise in adults (mean age=57 years)
and in males (95%). Multiple tumours were detected in 16 cases (20.5%),
and five of these were bilateral (6.5%). One of the multifocal tumours
involved an intra-parotideal lymph node and the laryngeal piriform
sinus. In addition, 13 cases (16.6%) were associated with other
malignancies. These data indicate that multiple (synchronous or
metachronous) WTs may occur more frequently than previously reported.
The high rate of multiple WTs detected in the current study may result
from extensive and accurate sampling of these neoplasms for
histopathological evaluation. Consequently, complete preoperative
work-up of patients harbouring parotideal tumours consistent with or
suspicious for WT is necessary. The work-up should include CT scans
and/or magnetic resonance imaging of both parotid glands, to exclude the
occurrence of multiple tumours, which may be clinically undetectable.
Also, fine needle aspiration biopsy may be an accurate tool for
excluding malignant neoplasms and for better planning subsequent
surgical procedures. These usually consist in (bilateral) superficial
parotidectomy and should be followed by long term follow up of the
patients, in view of possible metachronous WTs, even after prolonged
time intervals.
8
UI - 11711824
AU - Valentini V; Fabiani F; Perugini M; Vetrano S; Iannetti G
TI -
Surgical techniques in the treatment of pleomorphic adenoma of the
parotid gland: our experience and review of literature.
SO - J Craniofac Surg 2001 Nov;12(6):565-8
AD - Department of Maxillofacial Surgery, University of Rome, La Sapienza,
Italy.
This paper presents a retrospective study carried out on a sample of 100
patients affected by pleomorphic adenoma of the parotid gland and
treated at the Department of Maxillofacial Surgery at the University of
Rome "La Sapienza" between January 1, 1989 and December 31, 1997. For
the diagnosis of this neoformation, cytological tests were performed on
material taken from the neoformation using fine needle aspiration and
ultrasound scan. In some selected cases, a CT examination of the head
and neck with medium contrast or Nuclear Magnetic Resonance (NMR) was
carried out. This study sets out to examine the most suitable treatment
to be followed for the removal of the pleomorphic adenoma of the parotid
gland. In 56 cases the patients underwent a superficial, conservative
parotidectomy. Forty one patients had a total parotidectomy with the
facial nerve left intact and one patient had a total parotidectomy where
the marginal mandibular nerve of the facial nerve was damaged. The
remaining two patients involved in the study were suffering from a
recurrent pleomorphic adenoma and in these two cases a total
parotidectomy was performed where the facial nerve was killed. The
removal of the cranial nerve VII in these patients proved necessary
because the nerve fibers had adhered to the surrounding scar tissue of
the tumor, either after previous surgery or due to repeated chronic
phlogosis of the gland.
9
UI - 11799590
AU - Morey-Mas M; Caubet-Biayna J; Gomez-Bellvert C; Iriarte-Ortabe JI
TI -
Carcinosarcoma of the submandibular and sublingual salivary glands. A
case report and review of the literature.
SO - Acta Stomatol Belg 1997 Jun;94(2):69-73
AD - Department of Oral and Maxillofacial Surgery, Son Dureta Hospital,
C/Andrea Doria 55, Insalud, Palma de Mallorca, Spain. mmorey@arrakis.es
Carcinosarcoma of the salivary gland is a rare lesion, estimated at 0.2%
of malignant salivary gland tumors [1, 2]. The present article describes
a case occurring in a 54-year-old man with a submandibular mass in the
right neck. Histologically, this lesion was a carcinosarcoma which
involves the submandibular and the sublingual glands. Its stromal
component was a chondrosarcoma and the epithelial one was an
undifferentiated carcinoma in the whole tumor, with areas of adenoid
cystic carcinoma in the sublingual gland. To our knowledge, we have not
found any previously reported carcinosarcoma involving the sublingual
gland.
10
UI - 11141923
AU - Bischofberger A; Linder T; Melik N; Schmid S
TI -
[Indications and effects of the SMAS in parotid surgery]
SO - Schweiz Med Wochenschr 2000;Suppl 125():112S-115S
AD - Klinik und Poliklinik fur Otorhinolaryngologie, Hals- und
Gesichtschirurgie, Universitatsspital Zurich, Frauenklinikstrasse 24
CH-8091 Zurich.
The superficial musculoaponeurotic system (SMAS) is of increasing
interest in parotid surgery as a means of reducing the incidence of
postoperative gustatory sweating (Frey's syndrome) and improving
cosmetic results. Between 1996 and 1998 the SMAS was dissected as a
separate plane in 25 patients undergoing parotid surgery for a benign
tumour or recurrent infection. After a minimal follow-up of 12 months,
all patients were investigated for gustatory sweating and cosmetic
appearance. All underwent the starch minor test to document the extent
and intensity of postoperative sweating. In a previous publication we
found a 43% incidence of Frey's syndrome after parotid surgery without
SMAS dissection and starch minor tests were positive in all 23 patients.
However, analysis of the current results in patients with SMAS
dissection revealed an incidence of Frey's syndrome of only 20%, the
results of starch minor tests being positive in 76% with a statistically
highly significant (p = 0.006) decrease in extent and intensity.
Cosmetic appearance was improved by reduction of the retromandibular
depression. Dissection of the SMAS in parotid surgery is indicated in
tumours not extending to the parotid capsula. It not only reduces the
incidence of Frey's syndrome, but also improves the cosmetic result.
11
UI - 11141924
AU - Marchal F; Sacoun A; Pieyre JM
TI -
[Advantage of lifting in parotidectomy]
SO - Schweiz Med Wochenschr 2000;Suppl 125():116S-121S
AD - francis.marchal@bluewin.ch
INTRODUCTION: A retrospective study is presented of surgical patients
undergoing simultaneous SMAS lifting technique and parotidectomy, with
evaluation of the incidence of clinical Frey's syndrome. METHODS: 40
patients were operated on between 1978 and 1999. The surgical technique
is described and the incidence of clinical Frey's syndrome as evaluated
by questionnaire is presented. RESULTS: The 36 patients who answered the
questionnaire were satisfied with the aesthetic result in terms of
hidden scar and defect filling. 2 patients complained of warm cheek
sensation during meals, without associated sweating. One patient who had
had superficial parotidectomy in 1978 and total parotidectomy for
recurrent pleomorphic adenoma in 1997 complained of Frey's syndrome.
CONCLUSION: Combination of the two techniques provides excellent
aesthetic results. In this study the incidence of clinical Frey's
syndrome was 2%, with an incidence of incomplete Frey's syndrome in 5.5%
of cases due to SMAS interposition.
12
UI - 11801983
AU - Urquhart A; Hutchins LG; Berg RL
TI -
Preoperative computed tomography scans for parotid tumor evaluation.
SO - Laryngoscope 2001 Nov;111(11 Pt 1):1984-8
AD - Department of Otolaryngology-Head & Neck Surgery, Marshfield Clinic,
Marshfield, Wisconsin, USA. urquhara@mfldclin.edu
OBJECTIVE: We sought to determine whether an advantage is obtained in
the routine use of computed tomography (CT) scans in preoperative
assessments of parotid tumors. METHODS: A prospective study of 32
consecutive cases of patients who underwent evaluation for
parotidectomies was performed. Twenty-nine received preoperative CT
scans. The scans were systematically reviewed to see if they correlated
with the clinical findings. Specifically, we compared clinical and CT
assessments of tumor size, location, density, and malignancy. Further
comparisons were performed based on postoperative tissue pathology.
RESULTS: In our series of patients, routine preoperative CT scans
resulted in the discovery of details not revealed on clinical
examination: some masses were found to be extra-parotid rather than
primary parotid tumors, some tumors deemed to be deep were superficial,
tumor density was more clearly identified, and certain pathology
correlates were clarified. Most importantly, there were instances of
detection of additional tumors in the same lobe, and in one instance in
the opposite lobe, that were not otherwise noticed. CONCLUSIONS: To
reduce errors of omission in the treatment of suspected parotid tumors,
it would seem appropriate to consider the inclusion of CT scans for the
routine preoperative evaluation of all parotid masses.
13
UI - 11801984
AU - Zbaren P; Schar C; Hotz MA; Loosli H
TI -
Value of fine-needle aspiration cytology of parotid gland masses.
SO - Laryngoscope 2001 Nov;111(11 Pt 1):1989-92
AD - Department of Otorhinolaryngology-Head and Neck Surgery, University of
Berne, Inselspital, Berne, Switzerland. peter.zbaeren@insel.ch
OBJECTIVE: To evaluate the usefulness and accuracy of fine-needle
aspiration cytology (FNAC) in the diagnosis of parotid gland masses.
STUDY DESIGN: Retrospective chart review of patients undergoing FNAC.
resected at the Department of Otorhinolaryngology-Head and Neck Surgery
at the University of Berne, Inselpital (Berne, Switzerland). Included in
the study were 228 cases with preoperative FNAC. In a retrospective
study the results of FNAC were analyzed and compared with the
corresponding histopathological diagnosis. RESULTS: Histological
evaluation revealed 65 malignant tumors and 163 benign lesions (150
neoplasms and 13 nonneoplastic lesions). The cytological findings were
nondiagnostic in 13 (5.7%), true-negative in 146 (64%), true-positive in
39 (17%), false-negative in 22 (9.8%) and false-positive in 8 (4.5%)
cases in detecting malignant tumors. Nineteen of 39 (49%) malignant
tumors (true-positive) and 123 of 146 (84%) benign lesions
(true-negative) were classified accurately. The accuracy, sensitivity,
and specificity were 86%, 64%, and 95% respectively. CONCLUSIONS:
Fine-needle aspiration cytology is a valuable adjunct to preoperative
assessment of parotid masses. Preoperative recognition of malignant
tumors may help prepare both the surgeon and patient for an appropriate
surgical procedure.
14
UI - 11801985
AU - Govindaraj S; Cohen M; Genden EM; Costantino PD; Urken ML
TI -
The use of acellular dermis in the prevention of Frey's syndrome.
SO - Laryngoscope 2001 Nov;111(11 Pt 1):1993-8
AD - Department of Otolaryngology, Mount Sinai Medical Center, New York, NY
10029, USA.
EDUCATIONAL OBJECTIVE: At the conclusion of this presentation, the
participant should be able to discuss the indications and advantages of
using acellular dermis in the prevention of post-parotidectomy gustatory
sweating (Frey's Syndrome). INTRODUCTION: Gustatory sweating is a common
postoperative problem and a challenge to treat. The purpose of this
study was to evaluate the role of acellular dermis in preventing
post-parotidectomy gustatory sweating. METHODS: Sixty-four patients were
randomly assigned to two groups. Group I consisted of 32 patients who
underwent a superficial lobe parotidectomy. Group II consisted of 32
patients who underwent a superficial lobe parotidectomy and underwent
intraoperative placement of acellular dermis within the parotid bed,
between the skin flap and the remaining parotid tissue. The implanted
volume of acellular dermis was determined by the amount required to
aesthetically restore lateral facial contour. All 64 patients were
evaluated for gustatory sweating by identical phone and mail
questionnaires. Thirty randomly chosen patients (group I = 15, group II
= 15) were evaluated using a modified Minor's Starch-Iodine Test (MSIT).
In all 30 patients, the MSIT was administered to both sides of the face.
RESULTS: The responses to questionnaires (N = 64) demonstrated the
subjective presence of gustatory sweating in 3 of 32 patients (9.3%) in
group I, whereas group II demonstrated a subjective incidence in 1 of 32
patients (3.1%). The objective incidence determined by those who
underwent the MSIT (n = 30) revealed a 40% (6) and 0% incidence of
Frey's Syndrome in groups I and II, respectively. The complication rate
in group I was 9% (3 seromas) and in group II it was 25% (7 seromas and
1 wound infection). CONCLUSIONS: Acellular dermis appears to be an
effective method for preventing post-parotidectomy gustatory sweating,
despite its higher complication rate.
15
UI - 11704434
AU - Bialek EJ; Osmolski A; Karpinska G; Fedorowicz M; Jakubowski W;
TI -
Zajkowski P; Serafin-Krol M
US-appearance of a Kuttner tumour resembling a malignant lesion:
US-histopathologic correlation.
SO - Eur J Ultrasound 2001 Dec;14(2-3):167-70
AD - Department of Diagnostic Imaging, Warsaw Medical University, Brodnowski
Hospital, ul. Kondratowicza 8, 03-242 Warsaw, Poland.
ebialek@mail.bbd.amwam.edu.pl
We present a case of unilateral Kuttner tumour in the right
submandibular gland. Its clinical course and ultrasound features
inclined us to include a malignant lesion in the differential diagnosis.
US-histopathologic correlation explained the ultrasound appearance of
the lesion.
16
UI - 11769651
AU - Zhu S; Wang X; Shao L
TI -
[A qualititative study on p16 mutiple tumor suppressor gene, ras
oncogene p21 and DNA content in parotid tumor and its' contiguous acini]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2001 Sep;36(5):361-3
AD - Department of Stomatology, Tongji Hospital Tongji Medical University,
Wuhan 430030, China.
OBJECTIVE: To determine the biologic characteristics of tumor's
contiguous acini and the relationship of recurrence or malignant
transformation. METHODS: With the use of immunohistochemistry and flow
cytometry, the features of p16, p21 and DNA expression in 68 tumors and
their contiguous acini were studied. RESULTS: The expression of p16 and
p21 gene were found in tumors that the possitive unit (PU) was higher
than normal acini (P < 0.01). The areas of expression were mainly
located in cytoplasm of gland duct cells. Strong possitives or weak
possitives could be observed in the tissues of malignant tumors and
their contiguous acini respectively, as well as the PU in the deep lobe
of recurrent parotid tumors in which the capsule was incomplete was
higher than that in the superficial lobe of primary parotid tumors with
complete capsule (P < 0.05). Futhermoer the levels of DI, S% and PI were
higher in perotid tumors and its contiguous acini than normal acini (P <
0.05). CONCLUSIONS: When p16 multiple tumor suppressor gene is lost and
oncogene p21 is mutated, the tumor's contiguous acini maybe in the
condition of "paraneoplasm" after parotid tumor removal, and it has a
strong ability of preliferation, which play an important role in
recurrent or malignant change of the parotid tumor.
17
UI - 11569926
AU - Skalova A; Starek; Kucerova V; Szepe P; Plank L
TI -
Salivary duct carcinoma--a highly aggressive salivary gland tumor with
HER-2/neu oncoprotein overexpression.
SO - Pathol Res Pract 2001;197(9):621-6
AD - Department of Pathology, Medical Faculty, Charles University, Plzen,
Czech Republic. skalova@fnplzen.cz
Salivary duct carcinoma (SDC) is a highly malignant salivary gland tumor
with aggressive clinical behavior, and is characterized by its
histological resemblance to invasive ductal carcinoma of the breast.
Overexpression and/or amplification of proto-oncogene Her2/neu has been
shown to influence both prognosis and treatment of breast cancer. Since
salivary duct carcinoma and ductal breast carcinoma share many common
characteristics, HER2/neu overexpression might also be important in SDC.
However, data on the expression of c-erbB2/HER2/neu in salivary gland
tumors are still scarce. Therefore, we have evaluated 15 cases of
salivary duct carcinomas (SDC) for HER2/neu overexpression using
immunohistochemistry with the HercepTest. Overexpression, identified as
strong or moderate membrane immunostaining, was observed in all but one
case of SDC in most neoplastic cells. Thus, our study suggests that
anti-HER2/neu therapy with Herceptin is beneficial for patients with
aggressive salivary duct carcinoma.
18
UI - 11745070
AU - Araujo VC; Loducca SV; Sousa SO; Williams DM; Araujo NS
TI -
The cribriform features of adenoid cystic carcinoma and polymorphous
low-grade adenocarcinoma: cytokeratin and integrin expression.
SO - Ann Diagn Pathol 2001 Dec;5(6):330-4
AD - Oral Pathology Department, Faculdade de Odontologia da Universidade de
Sao Paulo, Sao Paulo, Brazil.
Cribriform areas are common features of both adenoid cystic carcinoma
and polymorphous low-grade adenocarcinoma. Both are malignant salivary
gland tumors that share similar histologic patterns, but with marked
distinct clinical behavior. This study was undertaken to improve the
accuracy of the histopathology diagnostic process, using an
immunohistochemical panel to differentiate adenoid cystic carcinoma from
polymorphous low-grade adenocarcinoma, with special concern to the
common cribriform areas shared by these tumors. Three-microm serial
sections of these tumors were submitted to the streptavidin-biotin
peroxidase immunotechnique against the monoclonal antibodies
anticytokeratins 7, 8, 14 and 19, and anti-integrins beta1, beta3, and
beta4. In the neoplastic lobules of adenoid cystic carcinoma cribriform
type, the spaces were mainly surrounded by cells negative for the
cytokeratins and integrins studied. In the solid type of adenoid cystic
carcinoma, the microcystic areas were caused by spaces lined by
neoplastic luminal cells positive for cytokeratins and presenting
integrins concentrated in the apical pole of these cells. The cribriform
areas of polymorphous low-grade adenocarcinoma were composed of cords of
luminal cells, positive for cytokeratins and showing integrins disposed
in a bipolar pattern. We concluded that cribriform areas of adenoid
cystic carcinoma and polymorphous low-grade adenocarcinoma are
histologically similar, although not identical. Indeed, their cellular
composition is distinct and can be distinguishable from one another by
the proteins of the cytoskeleton, by the integrins, or both. Copyright
2001 by W.B. Saunders Company
19
UI - 11779434
AU - Shi Q; Zhang T; Xue Q; Fan K; Sun G; Yan X; Shou B; Yu B
TI -
Clinicopathologic study of mucosa-associated lymphoid tissue lymphoma of
the salivary gland.
SO - Chin Med J (Engl) 2001 Jan;114(1):44-7
AD - Department of Pathology, Nanjing General Hospital of PLA, Nanjing
210002, China.
OBJECTIVE: To study the histopathologic features and pathogenesis of
mucosa-associated lymphoid tissue lymphoma (MALT-oma) of salivary
glands. METHODS: Clinical data, paraffin-embedded sections,
immunohistochemical slides (SP method) and electron microscopic features
of surgical specimens of 32 cases of salivary gland MALT-oma were
studied. RESULTS: The patients were 27 males and 5 females, with a mean
age of 54.76 years. The lesions were located in the parotid area in 17
cases, and in the submandibular gland in the remaining 15 cases. Much of
the MALT-oma was replaced by infiltration of a great amount of
centrocyte-like cells (CCL) as background and occasional large cells
(centroblast- or immunoblast-like). In MALT-omas "lymphoepithelial
lesions" were present. Immunohistochemically, CD20 expression was found
to be positive and CD45RO expression was negative in all MALT-omas.
CONCLUSION: Most of the MALT-omas are low grade malignant tumors and
have a "homing back" phenomenon. The cases were managed by surgery and
chemotherapy. In a few MALT-omas which turned into high grade malignant
tumors, the prognosis was poor. Acquired MALT may develop as a reaction
to autoimmune disease and infection. Hyper-immune reaction and MALT
hyperplasia under stimulation may result in myoepithelial sialadenitis
and lead to MALT-oma of the salivary gland.
20
UI - 11812346
AU - Li Z; Tang P; Xu Z
TI -
[Clinico-pathological significance of microvessel density and vascular
endothelial growth factor expression in adenoid cystic carcinoma of
salivary glands]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2001 May;36(3):212-4
AD - Department of Head Neck Surgery, Cancer Hospital Chinese Academy of
Medical Science, Peking Union Medical College, Beijing 100021, China.
OBJECTIVE: To evaluate the clinical significance of microvessel
density(MVD) and vascular endothelial growth factor(VEGF) expression in
adenoid cystic carcinoma of salivary glands. METHODS:
Immunohistochemical staining(SP) was used to quantify MVD and VEGF
expression in specimens from 55 patients with adenoid cystic carcinoma
of salivary glands. SPSS statistical software was used. RESULTS: High
VEGF expression was correlated with tumor site and stage (P = 0.0398, P
= 0.0175), but not with local recurrence, distant metastasis, regional
lymph node metastasis, histological classification and survival rate. A
significant correlation was not noted between MVD and the above
variables. The mean MVD in cases of high VEGF expression was
significantly higher than those in cases of low VEGF expression (P =
0.0202). CONCLUSIONS: In adenoid cystic carcinoma of salivary glands,
MVD and VEGF may be served as a prognostic factor which needs further
study, but there is a significant positive correlation between MVD and
VEGF expression.
21
UI - 11825927
AU - Hew WS; Carey FA; Kernohan NM; Heppleston AD; Jackson R; Jarrett RF
TI -
Primary T cell lymphoma of salivary gland: a report of a case and review
of the literature.
SO - J Clin Pathol 2002 Jan;55(1):61-3
AD - Department of Pathology, Ninewells Hospital and Medical School, Dundee
DD1 9SY, UK. roger.w.hew@tuht.scot.nhs.uk
Lymphoma of the salivary gland accounts for 5% of cases of extranodal
lymphoma and 10% of malignant salivary gland tumours. Most primary
salivary gland lymphomas are B marginal zone lymphomas arising on a
background of sialadenitis associated with autoimmune disorders such as
Sjorgen's syndrome. Primary T cell lymphoma of the salivary gland is
rare. This report describes a case of primary T cell lymphoma arising in
the parotid gland of an elderly white man, which was notable for its
striking resemblance to a B cell extranodal marginal zone lymphoma.
Immunohistochemistry and gene rearrangement studies confirmed the clonal
T cell nature of the tumour. There was no molecular evidence of
Epstein-Barr virus (EBV) infection of neoplastic or surroundings cells.
Only 14 cases of primary T cell lymphoma of the salivary glands have
been recorded in the literature, most being from the Orient and having
extremely variable prognosis. Those with a T/natural killer cell
phenotype are associated with EBV infection. This case highlights the
fact that T cell lymphoma in the salivary gland can mimic closely the
morphological features of B cell extranodal marginal zone lymphoma.
22
UI - 11757220
AU - Dabrowska M; Jorasz I; Duda-Krol W; Polubiec A
TI -
[Pseudolymphoma in patients with primary Sjogren's syndrome]
SO - Pol Merkuriusz Lek 2001 Aug;11(62):162-4
AD - Klinika Chorob Wewnetrznych, Pulmonologii i Alergologii Akademii
Medycznej w Warszawie, SP CSK.
Sjogren's syndrome is an inflammatory autoimmune disease affecting
primarily the exocrine glands. In the abscence of other autoimmune
diseases it is classified as primary Sjogren's syndrome. Patients with
primary syndrome have about 40 times higher relative risk of developing
lymphoma then normal population, which offers a possibility to study
malignant transformation's mechanisms in these patients. In the study we
report a case of a woman with pseudolymphoma. The clinical diagnose used
to be based on symptoms of proliferate disease, quetionnable
histological evaluation and good response to steroids. Nowadays,
applying advanced molecular techniques make it possible to diagnose
lymphoma in labial salivary biopsy much earlier. It allows recognizing
an incipient lymphoma in a group of patients with primary Sjogren's
syndrome. Therefore so-called pseudolymphoma can usually be diagnosed as
either benign or malignant lymphoproliferative lesions.
23
UI - 11807854
AU - Eichhorn KW; Arapakis I; Ridder GJ
TI -
Malignant non-Hodgkin's lymphoma mimicking a benign parotid tumor:
sonographic findings.
SO - J Clin Ultrasound 2002 Jan;30(1):42-4
AD - Department of Otorhinolaryngology-Head and Neck Surgery, University of
Freiburg, Killianstrasse 5, D-79106 Freiburg, Germany.
We report the case of an extranodal non-Hodgkin's lymphoma mimicking a
benign tumor in the left parotid gland of a 71-year-old woman. The
clinical presentation of the painless, mobile mass was suggestive of a
benign parotid tumor such as an adenoma. The intraglandular tumor
appeared sonographically as a well-circumscribed, hypoechoic,
homogeneous, lobulated mass with mild distal sound enhancement. Power
Doppler sonography showed marked intratumoral vascularization. The tumor
was resected by lateral lobectomy of the parotid gland and was found
histopathologically to be a diffuse large B-cell lymphoma. Copyright
2002 John Wiley & Sons, Inc.
24
UI - 11698848
AU - Larson DL
TI -
Management of the recurrent, benign tumor of the parotid gland.
SO - Plast Reconstr Surg 2001 Sep 1;108(3):734-40
AD - Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee
53226, USA. dlarson@mcw.edu
On occasion, the salivary gland surgeon is faced with clinical
management questions related to the treatment of parotid gland tumors.
Some of these are intraoperative and include margin of resection,
management of the facial nerve when tumor abuts its branches, judicious
use of lymphadenectomy, and the appropriateness of nerve grafting. Other
questions concern postoperative care-such as the use of radiation
therapy, reoperation when a malignancy is reported after surgery, timing
of follow-up, and management of a recurrent, benign tumor. Although all
of these issues cannot be addressed in one review article, the author
has attempted to offer a rational approach to one of the most
perplexing-the recurrent, benign tumor. The recommendations offered are
based on the literature and a clinical experience of two decades of
salivary gland surgery. Within this review a number of other management
issues noted above are also addressed.
25
UI - 11785118
AU - Scarpellini F; Marucci G; Foschini MP
TI -
[Myoepithelial differentiation markers in salivary gland neoplasia]
SO - Pathologica 2001 Dec;93(6):662-7
AD - Dipartimento di Oncologia, Universita di Bologna, Ospedale Bellaria, Via
Altura 3, I-40139 Bologna, Italia.
Salivary gland tumors frequently present myoepithelial cell
differentiation that is not always easily identified on routinely
stained sections. Recently novel markers of myoepithelium have been
studied, such as calponin (CALP), caldesmon (CALD), and smooth muscle
myosin heavy chain. These markers, together with smooth muscle actin may
be useful tools for identifying myoepithelial cells. We
immunohistochemically studied a series of 23 benign and malignant
salivary gland tumors using antibodies to these four markers. The tumors
were classified as follows: pleomorphic adenoma (n = 8), basal cell
adenoma (n = 3), myoepithelioma with plasmacytoid cells (n = 2),
epithelial-myoepithelial cell carcinoma (n = 6) and adenoid cystic
carcinoma (n = 4). All tumors were positive for at least one of the four
markers. CALP and smooth muscle actin were the markers more frequently
expressed. Positivity was mostly located in the myoepithelial cells that
constitute the external layer of the glandular or tubular neoplastic
structures. In poorly differentiated epithelial myoepithelial
carcinomas, composed of solid sheets of neoplastic cells and sometimes
of clear cells, immunohistochemical staining for myoepithelial markers
evidenced rudimentary glandular structures. CALP and smooth muscle actin
were positive in the two cases of myoepithelioma with plasmacytoid
cells. In conclusion, the combined staining with four markers helps to
disclose myoepithelial cell differentiation and can be a useful tool for
the correct histopathological diagnosis of salivary gland tumors. Among
the four markers studied, CALP and smooth muscle actin were the most
useful to identify myoepithelial cell differentiation.
26
UI - 11833658
AU - Hayashi K; Shimamoto F; Takata T; Yasui W
TI -
Epithelial-myoepithelial carcinoma of the parotid gland with adenoid
cystic carcinoma-like features: a case report with immunohistochemical
study.
SO - Hiroshima J Med Sci 2001 Dec;50(4):101-4
AD - First Department of Pathology, Hiroshima University School of Medicine,
Japan.
A 69-year-old japanese female with epithelial myoepithelial carcinoma
(EMC) in the parotid gland is reported. The tumor, 3.5 x 4.0 x 1.5 cm in
size, was located in the left parotid gland. Histopathological
examination of the surgically removed tumor revealed that it was
composed of double-layered, tubule-like structures formed by inner
eosinophilic ductal cells and outer clear cells, as well as solid clear
cell nests. The unique histological finding of this tumor was that it
had a cribriform-like arrangement of myoepithelial cells resembling an
adenoid cystic carcinoma. On the other hand, the typical ductal and
myoepithelial components of EMC showed the usual biphasic pattern and
the expected immunophenotypes, with expression of low molecular weight
cytokeratins, CAM 5.2 and EMA in the ductal part, and smooth muscle
actin, S-100 protein, and vimentin in the myoepithelial component.
27
UI - 11786752
AU - Shih WJ; Ghesani N; Hongming Z; Alavi A; Schusper S; Mozley D
TI -
F-18 FDG positron emission tomography demonstrates resolution of
non-Hodgkin's lymphoma of the parotid gland in a patient with Sjogren's
syndrome: before and after anti-CD20 antibody rituximab therapy.
SO - Clin Nucl Med 2002 Feb;27(2):142-3
AD - Nuclear Medicine Service, Lexington VA Medical Center, the University of
Kentucky Medical Center, 40511, USA. wshih0@pop.uky.edu
28
UI - 11752900
AU - Schlott T; Nagel H; Laskawi R; Eiffert H; Droese M
TI -
Genetic analysis of the human oncoprotein MDM2 in benign and malignant
tumors of the salivary gland.
SO - Pathobiology 2001;69(2):67-76
AD - Department of Cytopathology, Georg August University, Gottingen,
Germany. tschlott@med.uni-goettingen.de
INTRODUCTION: Genetic alterations of oncogene MDM2 promote malignant
transformation of several human tumors. In tumors of the salivary gland,
however, the genetic status of MDM2 has not been evaluated so far.
METHODS AND RESULTS: Benign and malignant tumors of the salivary gland
(6 pleomorphic adenomas, 3 Warthin's tumors, 1 adenocarcinoma, 1 basal
cell adenocarcinoma, 1 mucoepidermoid carcinoma, 3 acinic cell
carcinomas, 2 adenoid cystic carcinoma, 1 squamous cell carcinoma) were
analyzed by fluorescence-based PCR techniques and immunochemistry for
MDM2 gene amplification, MDM2 gene expression, MDM2 gene mutation, MDM2
RNA splicing and MDM2 accumulation. Data show that all samples contained
nonamplified MDM2 genes with nonmutant zinc finger regions. However, in
two benign and two malignant samples, novel MDM2 mRNA splicing variant
types 1 and 2 were detected. Furthermore, three malignant tumors
revealed significant nuclear MDM2 accumulation. Correlation between
levels of MDM2 mRNA and MDM2 protein could not be detected in the
specimens. CONCLUSION: The present study suggests that MDM2 gene
mutation and gene amplification do not contribute to MDM2 accumulation
detected in malignant tumors of the salivary gland. However, the role of
novel MDM2 splicing variants in MDM2 expression and malignant
transformation must be elucidated further. Copyright 2001 S. Karger AG,
Basel
29
UI - 11845580
AU - Kovacic M
TI -
[Metastasis of cutaneous squamous cell carcinoma of the face into the
parotid area]]
SO - Lijec Vjesn 2001 Sep-Oct;123(9-10):248-50
AD - Opca bolnica Zadar, Primljeno 3. svibnja 2000.
Presence of planocellular skin carcinoma always implies the possibility
of disease spreading into regional lymph nodes. The average occurrence
of metastasis of this face carcinoma is about 5% (from 0.5% to 19.5%).
This paper presents seven patients with lymphogenic metastasis of
planocellular carcinoma of face skin into parotid region. All patients
were treated surgically, and in three patients with extracapsular
spreading of metastasis radiation therapy was applied. The choice of the
extent of surgery was made on the basis of clinical status. In three
patients with small solitary metastases superficial parotidectomy was
performed as the only treatment method, and during the three-year follow
up the disease did not recur. in other four patients radical procedure
with total parotidectomy and elective neck dissection was done due to
greater number and size of parotid gland lymph nodes. During the second
year of treatment of these patients, disease dissemination and lethal
outcome were recorded. The importance of surgical treatment of the
primary tumor is emphasized, as well as obligatory pathohistologic
examination of the tissue (determination of the depth of invasion,
edges), and frequent follow-up of patients at risk with the aim of early
detection of recurrence and occult metastases.
30
UI - 11765454
AU - Soboczynski R; Wojnowski W
TI -
[Pleomorphic adenoma of atypical location]
SO - Otolaryngol Pol 2001;55(3):335-7
AD - Oddzial Laryngologiczny Wielospecjalistycznego Szpitala Puszczykowo
s.p.z.o.z. w Puszczykowie.
The authors described 2 cases of adenoma pleomorphum localised out of
salivary glands. One of them was located in mucous of cheek and another
one on the palate. All patients were treated surgically.
31
UI - 11780497
AU - Cai Y; Qiu W; He R
TI -
[Antitumor effect of radiation combined with tumor draining lymphocytes
on human ACC-M cell in vitro]
SO - Zhonghua Kou Qiang Yi Xue Za Zhi 2000 Jul;35(4):245-7
AD - Department of Oral Maxillofacial Surgery, School of Stomatology,
Shanghai Second Medical University, Shanghai 200011, China.
OBJECTIVE: To find whether there is any synergistic effect of radiation
combined with interleukin-2(IL-2) activated tumor draining lymph nodes
lymphocytes (DNL) from oral-carcinoma patients on high-lung metastatic
salivary adenoid cystic carcinoma cell line(ACC-M). METHODS:
Colony-forming test was used to investigate antitumor effect and
analyzed using linear-quadratic(LQ) equation and single hit multi
targets equation. RESULTS: The ratio of effect to targets was 25:1. The
cytotoxicity of DNL was 49.06%. Radiation combined with DNL showed
higher antitumor activity compared with radiation alone, alpha value, Dq
and S2 were 0.7688 and 0.342 0; 1.5901 and 0.5995; 0.4481 and 0.1135
respectively(P < 0.05). CONCLUSIONS: It indicates that in initial region
of survival curve, DNL significantly increased sublethal damage on
ACC-M.
32
UI - 11842929
AU - Voz ML; Van de Ven WJ; Kas K
TI -
First insights into the molecular basis of pleomorphic adenomas of the
salivary glands.
SO - Adv Dent Res 2000 Dec;14():81-3
AD - Laboratory for Molecular Oncology, Center for Human Genetics, University
of Leuven & Flanders Interuniversity Institute for Biotechnology,
Belgium. marianne.voz@med.kuleuven.ac.be
Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign
tumor originating from the major and minor salivary glands. Eighty-five
percent of these tumors are found in the parotid gland, 10% in the minor
(sublingual) salivary glands, and 5% in the submandibular gland. It is
the most common type of salivary gland tumor, accounting for almost 50%
of all neoplasms in these organs. In fact, after the first observation
of recurrent loss of chromosome 22 in meningioma, this was the second
type of benign tumor for which non-random chromosomal changes were
reported. The rate of malignant change with the potential to metastasize
has been reported to be only 2 to 3%, and only a few cases of
metastasizing pleomorphic salivary gland adenomas have been described to
date. The fact that these tumors arise in organs located in an
ontogenetic transitional zone, a region where endoderm and ectoderm
meet, might be one of the reasons for the often-problematic
histopathological classification. This type of benign tumor has been
cytogenetically very well-characterized, with several hundreds of tumors
karyotyped. In addition to the cytogenetic subgroup with an apparently
normal diploid stemline (making up approximately 30% of the cases),
three major cytogenetic subgroups can be distinguished. In addition to a
subgroup showing non-recurrent clonal abnormalities, another subgroup is
various translocations involving 12q15. By far the largest cytogenetic
subgroup, however, consists of tumors with chromosome 8 abnormalities,
mainly showing translocations involving region 8q12. The most frequently
encountered aberration in this group is a t(3;8)(p21;q12).
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