UI - 11554627
AU - Harden SV; Tan LT
Treatment of localized carcinoma of the penis: a survey of current
practice in the UK.
SO - Clin Oncol (R Coll Radiol) 2001;13(4):284-7; quiz 288
AD - Addenbrooke's Hospital, Cambridge, UK.
Consensus opinion from published reports on the management of localized
carcinoma of the penis recommends that patients with small, distal,
non-poorly differentiated lesions should be offered penis-conserving
treatment, while those with larger or more advanced lesions should be
considered for amputative surgery. A questionnaire survey was sent to
289 urologists and 237 oncologists in the UK to assess their practice
for the treatment of localized carcinoma of the penis. Consultants were
asked to choose between penis-conserving surgery, amputation or
radiotherapy as their preferred treatment for four examples of localized
disease. Oncologists were also asked to indicate their preferred
radiation modality (external beam radiotherapy or brachytherapy). For
treating a small lesion situated distally on the glans penis, 56.7% of
urologists and 94.5% of oncologists preferred penis-conserving methods;
28.8% of urologists and one oncologist preferred partial or total
amputation. In total, 43.2% of urologists would consider amputative
surgery for this lesion compared with only 5.5% of oncologists. Only
23.3% of oncologists considered using brachytherapy. For a 4 cm lesion
situated distally, the majority of urologists surveyed (82.0%) preferred
amputative surgery, while the majority of oncologists (68.5%) preferred
conservative treatment. For a 1.5 cm lesion extending on to the penile
shaft, 68.5% of urologists preferred amputative surgery while 85.0% of
oncologists preferred penis-conserving options. For a 4 cm lesion
extending on to the shaft, the vast majority of urologists (86.5%)
preferred amputation as treatment compared with only 36.9% of
oncologists. The results of the survey suggested that clinicians tended
to favour the treatment modality of which they have most experience. As
such, urologists tended to prefer surgery while clinical oncologists
tended to prefer radiotherapy, irrespective of the size and position of
the primary tumour or consensus opinion. These results emphasize the
importance of multidisciplinary clinics and site specialization, so that
both clinicians and patients can make informed choices about optimal
treatment, based on the knowledge of all available treatment options.
UI - 11773353
AU - Harper M; Arya M; Shah PJ
A lump in the penis.
SO - J R Soc Med 2002 Jan;95(1):38-9
AD - Institute of Urology, 48 Riding House Street, London W1W 7EY, UK.
UI - 10900037
AU - Sastre-Garau X; Favre M; Couturier J; Orth G
Distinct patterns of alteration of myc genes associated with integration
of human papillomavirus type 16 or type 45 DNA in two genital tumours.
SO - J Gen Virol 2000 Aug;81(Pt 8):1983-93
AD - Unite Mixte Institut Pasteur/INSERM (U.190), Institut Pasteur, 25 rue du
Docteur Roux, F-75724 Paris cedex 15, France.
We previously described two genital carcinomas (IC2, IC4) containing
human papillomavirus type 16 (HPV-16)- or HPV-18-related sequences
integrated in chromosomal bands containing the c-myc (8q24) or N-myc
(2p24) gene, respectively. The c-myc gene was rearranged and amplified
in IC2 cells without evidence of overexpression. The N-myc gene was
amplified and highly transcribed in IC4 cells. Here, the sequence of an
8039 bp IC4 DNA fragment containing the integrated viral sequences and
the cellular junctions is reported. A 3948 bp segment of the genome of
HPV-45 encompassing the upstream regulatory region and the E6 and E7
ORFs was integrated into the untranslated part of N-myc exon 3, upstream
of the N-myc polyadenylation signal. Both N-myc and HPV-45 sequences
were amplified 10- to 20-fold. The 3' ends of the major N-myc transcript
were mapped upstream of the 5' junction. A minor N-myc/HPV-45 fusion
transcript was also identified, as well as two abundant transcripts from
the HPV-45 E6-E7 region. Large amounts of N-myc protein were detected in
IC4 cells. A major alteration of c-myc sequences in IC2 cells involved
the insertion of a non-coding sequence into the second intron and their
co-amplification with the third exon, without any evidence for the
integration of HPV-16 sequences within or close to the gene. Different
patterns of myc gene alterations may thus be associated with integration
of HPV DNA in genital tumours, including the activation of the
protooncogene via a mechanism of insertional mutagenesis and/or gene
UI - 11801919
AU - Motoori K; Takano H; Ueda T; Ishihara M
Sclerosing lipogranuloma of male genitalia: CT and MR images.
SO - J Comput Assist Tomogr 2002 Jan-Feb;26(1):138-40
AD - Department of Radiology, Chiba University Hospital, Chiba, Japan.
We report the imaging findings of sclerosing lipogranuloma. Sclerosing
lipogranuloma is a peculiar granulomatous fatty tissue reaction. The
majority of the cases occur in the genital and urinary tracts. To our
knowledge, the CT and MR images of this rare entity have not been
reported in the English literature. We present a case that was suspected
to be sclerosing lipogranuloma of the male genitalia on CT and MR images
and was diagnosed by open biopsy.
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