Table of Contents
1
UI - 12007217
AU - Olivier M; Eeles R; Hollstein M; Khan MA; Harris CC; Hainaut P
TI -
The IARC TP53 database: new online mutation analysis and recommendations
to users.
SO - Hum Mutat 2002 Jun;19(6):607-14
AD - Molecular Carcinogenesis Group, International Agency for Research on
Cancer, World Health Organization, Lyon, France.
Mutations in the tumor suppressor gene TP53 are frequent in most human
cancers. Comparison of the mutation patterns in different cancers may
reveal clues on the natural history of the disease. Over the past 10
years, several databases of TP53 mutations have been developed. The most
extensive of these databases is maintained and developed at the
International Agency for Research on Cancer. The database compiles all
mutations (somatic and inherited), as well as polymorphisms, that have
been reported in the published literature since 1989. The IARC TP53
mutation dataset is the largest dataset available on the variations of
any human gene. The database is available at www.iarc.fr/P53/. In this
paper, we describe recent developments of the database. These
developments include restructuring of the database, which is now
patient-centered, with more detailed annotations on the patient
(carcinogen exposure, virus infection, genetic background). In addition,
a new on-line application to retrieve somatic mutation data and analyze
mutation patterns is now available. We also discuss limitations on the
use of the database and provide recommendations to users. Copyright 2002
Wiley-Liss, Inc.
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