Table of Contents
1
UI - 12149740
AU - Kim Y; Donoff RB; Wong DT; Todd R
TI -
The nucleotide: DNA sequencing and its clinical application.
SO - J Oral Maxillofac Surg 2002 Aug;60(8):924-30
AD - Department of Oral and Maxillofacial Surgery, Harvard School of Dental
Medicine and Massachusetts General Hospital, Boston, MA 02115, USA.
Information determining cellular structure and function is contained in
chromosomal DNA. Genes, regions of DNA encoding this information, are
composed of specific sequences of nucleotides. DNA sequencing methods
have been developed to identify these sequences. Even subtle alteration
(or mutation) of these sequences can lead to many human syndromes and
diseases. This article reviews 1) the structure of the nucleotide, 2)
the methods of DNA sequencing, and 3) its recent clinical application in
analysis of the nevoid basal cell carcinoma syndrome. Copyright 2002
American Association of Oral and Maxillofacial Surgeons.
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