UI - 11843065
AU - Kouraklis G; Misiakos E; Glinavou A; Raftopoulos J; Karatzas G
Management of enterochromaffin-like gastric carcinoid tumour
metastasized to the liver.
SO - Scand J Gastroenterol 2002 Feb;37(2):246-8
AD - 2nd Dept. of Propedeutic Surgery, University of Athens, Faculty of
Medicine, Greece. firstname.lastname@example.org
We report the rare case of a patient suffering from pernicious anaemia
and a history of flushing and diarrhoea. The patient was found to have
microcarcinoids with multiple gastric polyps and a solitary liver
metastasis. He was successfully managed with subtotal gastrectomy, while
the liver metastasis was cured by Interferon-alpha and octreotide
UI - 12037460
AU - Fetil E; Ozkan S; Gurler N; Kusku E; Arda F; Gunes AT
Recurrent leser-trelat sign associated with two malignancies.
SO - Dermatology 2002;204(3):254-5
UI - 12080244
AU - Cooper MA; Smith A; Khalifa M
Carcinoid syndrome from gastrointestinal carcinoid tumor without distant
SO - J Clin Gastroenterol 2002 Jul;35(1):106-7
UI - 12086896
AU - Zyromski NJ; Kendrick ML; Nagorney DM; Grant CS; Donohue JH; Farnell MB;
Thompson GB; Farley DR; Sarr MG
Duodenal carcinoid tumors: how aggressive should we be?
SO - J Gastrointest Surg 2001 Nov-Dec;5(6):588-93
AD - Gastroenterology Research Unit and Department of Surgery, Mayo Clinic,
Rochester, Minn. 55905, USA.
Duodenal carcinoid tumors are uncommon. It is not known whether they
behave more like carcinoid tumors in the appendix (indolent course) or
those in the ileum (often virulent)-crucial information for determining
the need for radical resection. A retrospective review at our tertiary
referral center (from 1976 to 1999) identified 27 patients with primary
duodenal carcinoid lesions, excluding functional islet cell tumors.
Endoscopic biopsy provided the diagnosis in 78% of patients. Treatment
was by endoscopic excision (n = 11), transduodenal excision (n = 8),
pancreaticoduodenectomy (n = 3), segmental distal duodenectomy (n = 2),
or palliative operation (n = 2). One patient did not undergo operation
because of comorbidity. Eighteen of 19 patients with tumors smaller than
2 cm remained disease free after local (endoscopic or transduodenal)
excision. The exception was a patient with a small periampullary
carcinoid lesion. In contrast, all four patients with carcinoid tumors 2
cm or larger who were resected for cure developed a recurrence (2 to 9
years postoperatively). We conclude that duodenal carcinoid tumors
smaller than 2 cm may be excised locally; to ensure complete resection
we recommend open transduodenal excision for tumors between 1 and 2 cm.
Endoscopic follow-up is indicated. It is unclear whether patients with
larger tumors benefit from more aggressive locoregional resection.
Ampullary/periampullary carcinoid tumors should be considered
separately, as their behavior is unpredictable.
UI - 12001676
AU - Patiutko IuI; Badalian KhV
[Surgical treatment of endocrine-cell tumors of
hepato-pancreatic-duodenal zone (comment of the editor)]
SO - Khirurgiia (Mosk) 2002;(4):17-21
Endocrine-cell tumors of hepatopancreatoduodenal zone are rare diseases.
Their rate doesn't exceed 1-4% of all tumors of this location. 79
patients with endocrine-cell tumors of hepatopancreatoduodenal zone were
treated, 67 of them underwent surgical treatment (operability was 67.1%)
Radical operations were performed in 45 patients
(gastropancreatoduodenal resection--17, distal resection of the
pancreas--16, tumor enucleation--5, hemihepatectomy--3, liver
resection--4). Prognosis of endocrine-cell tumors of
hepatopancreatoduodenal zone is relatively favorable. In radically
operated patients the presence of metastases to lymph nodes doesn't
influence long-term results which are better than ones of chemo- or
radiotherapy. Correlation between long-term results of surgery and age
of patients, tumor sizes and its histologic structure was not revealed.
Radicality of surgery is the only factor influencing prognosis. It is
necessary to expand indications for extended operations, and to perform
multi-stage operations in some cases of recurrences.
UI - 11899115
AU - Kaerlev L; Teglbjaerg PS; Sabroe S; Kolstad HA; Ahrens W; Eriksson M;
Guenel P; Gorini G; Hardell L; Cyr D; Zambon P; Stang A; Olsen J
The importance of smoking and medical history for development of small
bowel carcinoid tumor: a European population-based case-control study.
SO - Cancer Causes Control 2002 Feb;13(1):27-34
AD - Department of Epidemiology and Social Medicine, University of Aarhus,
OBJECTIVE: Little is known about the etiology of small bowel carcinoid
tumor (SBC), but a few studies have pointed to certain medical and
lifestyle factors as potential risk factors. This study aims to evaluate
these findings and to identify new associations. METHODS: A
population-based European multicenter case-control study was conducted
from 1995 through 1997. Incident histologically verified 35-69 year-old
SBC cases (n = 99) and 3335 controls were recruited; 84 cases and 2070
controls were interviewed. RESULTS: Ever being a smoker was associated
with SBC (odds ratio = 1.9; 95% confidence interval 1.1-3.2) and
increased risk estimates were seen for all smoking categories. SBC was
associated with previous gallstone disease and ovariectomy, but only
when these conditions occurred within two years prior to the SBC
diagnosis. No association was seen for a history of cholecystitis, liver
cirrhosis, ulcerative disease, or Crohn's disease. Intake of alcoholic
beverages--as well as medical treatments with radioactive substances,
hormones, or corticosteroid tablets--were not associated with SBC.
CONCLUSIONS: This study indicates that tobacco smoking is a risk factor
for SBC. The associations with gallstone and ovarian diseases may be due
to enhanced medical surveillance during the early phase of the cancer
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