UI - 11420261
AU - Gottlieb S
Scientists screen embryo for genetic predisposition to cancer.
SO - BMJ 2001 Jun 23;322(7301):1505
UI - 7663514
AU - Wang XW; Yeh H; Schaeffer L; Roy R; Moncollin V; Egly JM; Wang Z;
Freidberg EC; Evans MK; Taffe BG; et al
p53 modulation of TFIIH-associated nucleotide excision repair activity.
SO - Nat Genet 1995 Jun;10(2):188-95
AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland 20892-4255, USA.
p53 has pleiotropic functions including control of genomic plasticity
and integrity. Here we report that p53 can bind to several transcription
factor IIH-associated factors, including transcription-repair factors,
XPD (Rad3) and XPB, as well as CSB involved in strand-specific DNA
repair, via its C-terminal domain. We also found that wild-type, but not
Arg273His mutant p53 inhibits XPD (Rad3) and XPB DNA helicase
activities. Moreover, repair of UV-induced dimers is slower in
Li-Fraumeni syndrome cells (heterozygote p53 mutant) than in normal
human cells. Our findings indicate that p53 may play a direct role in
modulating nucleotide excision repair pathways.
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