UI - 3953697
AU - Sedlacek TV; Cunnane M; Carpiniello V
Colposcopy in the diagnosis of penile condyloma.
SO - Am J Obstet Gynecol 1986 Mar;154(3):494-6
To determine the incidence of penile condyloma in a group of high-risk
men, we carried out colposcopy and biopsy of suspicious lesions in 51
men. All men were partners of women with condyloma. Of these men, 45
were found to have histologic evidence of condyloma, and only eight of
these had grossly visible disease.
UI - 12228756
AU - Pow-Sang MR; Benavente V; Pow-Sang JE; Morante C; Meza L; Baker M;
Cancer of the penis.
SO - Cancer Control 2002 Jul-Aug;9(4):305-14
AD - Department of Urology, Instituto de Enfermedades Neoplasicas Dr Eduardo
Caceres Graziani, Lima, Peru. firstname.lastname@example.org
BACKGROUND: Cancer of the penis is an uncommon malignancy in developed
countries, but the incidence is as high as 17% of all male cancers in
some undeveloped countries. The surgical management of this disease has
improved due to better knowledge of risk for metastasis and newer
imaging technologies to assess the regional lymph nodes. METHODS: We
review the literature on incidence, etiology, pathology, clinical
presentation, staging, and management of penile cancer. We present our
institutional experience with 160 patients who underwent extended
ilioinguinal lymph node dissection, as well as with 7 patients who
underwent a modified lymph node dissection. RESULTS: Better
understanding of pathologic features allow for stratification of
patients into low, intermediate, or high risk for lymph node
involvement. Lymphatic mapping to this stratification improves selection
of patients who might benefit from lymph node dissection after excision
of the primary lesion. Our experience with lymph node dissection yielded
a high incidence of positive lymph nodes when lymphadenopathy was
present. The recent use of a modified lymph node dissection has
minimized morbidity. Current chemotherapy agents are ineffective in this
disease. CONCLUSIONS: Pathologic features of the primary lesion and the
incorporation of lymphatic mapping have improved the selection of
patients who might benefit from lymph node dissection. The use of a
modified lymph node dissection in selected patients has decreased
morbidity. Effective chemotherapy agents are needed in the management of
advanced penile cancer.
UI - 12352399
AU - Coblentz TR; Theodorescu D
Morbidity of modified prophylactic inguinal lymphadenectomy for squamous
cell carcinoma of the penis.
SO - J Urol 2002 Oct;168(4 Pt 1):1386-9
AD - Department of Urology, University of Virginia Health Sciences Center,
Charlottesville, 22908, USA.
PURPOSE: Classic inguinal lymphadenectomy for penile cancer is
associated with significant immediate and long-term sequelae limiting
its use in the prophylactic setting. Preservation of the saphenous vein
has been shown in the gynecological oncology literature to reduce the
morbidity of inguinal lymphadenectomy. In addition, saphenous vein
sparing coupled with thick skin flaps and limited lymphadenectomy for
penile cancer has been associated with minimal morbidity. Reports on
saphenous vein preservation in men undergoing inguinal lymphadenectomy
are limited and, therefore, we reviewed our experience. MATERIALS AND
METHODS: We reviewed retrospectively 11 patients with stage pT1-T3 cN0
M0 grades I to III carcinoma of the penis or penile urethra who
underwent bilateral inguinal lymphadenectomy with saphenous vein sparing
patients 1 underwent simultaneous penectomy and 10 had undergone a
partial or total penectomy previously. Short-term and long-term
postoperative complications were defined as minor-did not require
significant medical intervention and included superficial skin edge
sloughing, seroma and lymphocele, and major-skin edge or flap necrosis,
wound infection, deep venous thrombosis or leg edema inhibiting return
to pretreatment activities. RESULTS: Mean followup was 9 months. The
saphenous vein was preserved in 19 groins and ligated in 3. Simultaneous
bilateral pelvic lymphadenectomy was performed in 5 patients. Nodal
disease was found in 5 of 11 (45%) patients on pathological review.
Minor short-term complications occurred in 8 of 22 (36%) groins, and
major complications included deep venous thrombosis in 1 case and a
small myocardial infarction in 1. There was no perioperative mortality.
Lower extremity lymphedema requiring more than temporary (less than 6
months) support hose management did not occur in any patient. There were
no inguinal recurrences during followup. CONCLUSIONS: Inguinal
lymphadenectomy with saphenous vein sparing and thick skin flaps appears
to offer excellent functional outcome in patients undergoing
prophylactic bilateral inguinal lymphadenectomy for high risk disease.
Early followup indicates that the local recurrence rate does not appear
to increase compared to similar patients reported on in the literature
treated with the classic dissection technique.
UI - 12271283
AU - Orengo I; Rosen T; Guill CK
Treatment of squamous cell carcinoma in situ of the penis with 5%
imiquimod cream: a case report.
SO - J Am Acad Dermatol 2002 Oct;47(4 Suppl):S225-8
AD - Department of Dermatology, Baylor College of Medicine, Houston, Texas,
A patient with widespread in situ squamous cell carcinoma of the glans
penis was successfully managed with topical application of 5% imiquimod
cream. Therapy with topical immune response modifiers may prove
beneficial in cases of superficial cutaneous carcinoma and may, if
future studies confirm our findings, play a role in settings in which
more destructive techniques may result in cosmetic defects or functional
impairment. The use of imiquimod for intraepithelial squamous cell
carcinoma of the anogenital area seems particularly logical because of
the strong correlation between this neoplasm and infection with human
UI - 8305023
AU - Morgan K
Male and female circumcision in Canada.
SO - CMAJ 1993 Nov 15;149(10):1382-3
UI - 7922925
AU - Jones M
SO - CMAJ 1994 Oct 1;151(7):915-6
UI - 12174131
AU - Calista D
Topical cidofovir for erythroplasia of Queyrat of the glans penis.
SO - Br J Dermatol 2002 Aug;147(2):399-400
UI - 11250799
AU - Zhang XH; Sun GQ; Yang Y; Zhang TH
Human papillomavirus and p53 protein immunoreactivity in condylomata
acuminatum and squamous cell carcinoma of penis.
SO - Asian J Androl 2001 Mar;3(1):75-7
AD - Department of Pathology, General Hospital of Nanjing Command, China.
AIM: To determine the immunoreactive pattern of human papillomavirus
(HPV) antigen and p53 protein in condylomata acuminatum (CA) and
squamous cell carcinoma (SCC) of penis. METHODS: Immunohistochemistry
for HPV and p53 were performed in 40 specimens of formalin fixed,
paraffin embedded tissues using a polyclonal (rabbit) antibody against
HPV and a monoclonal (mouse) antibody against human p53 protein. Twenty
one cases of CA and nineteen cases of SCC were examined. RESULTS: HPV
antigen was detected in all 21 CA and 2 penile SCC. p53 protein
overexpression was observed in 12 of 19 (63%) SCC in which 6 cases were
strong positive. Five of 21 CA (24%) showed low-grade p53 protein
overexpression. CONCLUSION: CA is related to HPV infection and some
cases show p53 protein low-grade overexpression. In contrast, p53
protein overexpression is common in penile SCC, which is seldom related
to HPV infection.
UI - 12238172
AU - Majamaa H; Reunala T
[Precancerous and malign lesions and the risk of penis carcinoma]
SO - Duodecim 2002;118(9):937-40
AD - TAYS:n iho- ja sukupuolitautien klinikka PL 2000, 33521 Tampere.
UI - 11773353
AU - Harper M; Arya M; Shah PJ
A lump in the penis.
SO - J R Soc Med 2002 Jan;95(1):38-9
AD - Institute of Urology, 48 Riding House Street, London W1W 7EY, UK.
UI - 11872774
AU - Bates AW; Baithun SI
Secondary tumours of the penis.
SO - J R Soc Med 2002 Mar;95(3):162-3
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