Stereotactic Radiosurgery in the Treatment of Metastatic Disease to the Brain
Li Liu, MD
Abramson Cancer Center of the University of Pennsylvania
Last Modified: November 1, 2001
Authors: Joseph C.T. Chen, Zbigniew Petrovich, Steven O'Day, et al.
Source: Neurosurgery, Volume 47:268-281, (August) 2000
IntroductionWhole brain radiation therapy (WBRT) has been the standard care for the majority of patients with brain metastasis. However, the outcome of these patients has been dismal due to both local and systemic failure. In this study, the researchers reported the outcome of patients with brain metastasis who underwent gamma knife stereotactic radiosurgery.
MethodA total of 190 patients who underwent gamma knife stereotactic radiosurgery for intracerebral metastatic tumors were included.
- Median survival after radiosurgery was 34 weeks.
- Median survival was significantly longer in patients with controlled systemic disease (>50 weeks) than with active systemic disease (28 weeks).
- 6% of treated lesions demonstrated late recurrence (>6 months after treatment) and 6% of lesions showed continued tumor progression despite radiosurgical treatment.