Second Malignancies after Treatment for Ewing's Sarcoma: A Report of Cess-studies
J. Dunst et al
Abramson Cancer Center of the University of Pennsylvania
Last Modified: November 1, 2001
Reviewers: Kenneth Blank, MD
Source: International Journal of Radiation Oncology, Biology and Physics September 1, 1998 Vol. 52, No. 2. P379
BackgroundAs the treatment of childhood cancer improves and more children are cured, there is a growing concern over the long-term toxicity of treatment. Possibly the mostconcerning toxicity is the development of a second tumor. Second tumors may be due to the treatment (chemotherapy and radiotherapy both can lead to tumor formation) orto genetics (children who have cancer maybe predisposed to developing a second cancer) or a combination of both. Two childhood tumors in particular have a high incidenceof second tumor formation: Ewing's sarcoma and retinoblastoma.
Ewing's sarcoma is a cancer that typically arises in the bones of teenagers and is treated with a combination of chemotherapy, surgery and radiotherapy. Because of reportsdetailing the formation of second cancers, the dose and amount of tissue receiving radiation has been reduced on most modern studies. In the September 1, 1998 issue of theInternational Journal of Radiation Oncology, Biology and Physics the German Ewing's Sarcoma Studies group reports the rate of second cancers in Ewing's patients whoreceived modern doses of radiotherapy.