Sentinel Lymph Node Procedure Is Highly Accurate in Squamous Cell Carcinoma of the Vulva
J. A. de Hullu, H. Hollema, D. A. Piers, et al.
Abramson Cancer Center of the University of Pennsylvania
Last Modified: November 1, 2001
Reviewers: Li Liu, MD
Source: Journal of Clinical Oncology, Volume 18:2811-2816, (August) 2000
Précis: Sentinel lymph node biopsy predicts metastasis of vulvar cancer
IntroductionA sentinel lymph node (SLN) is the first lymph node along the route of lymphatic drainage from a primary tumor. Sentinel lymph nodes receiving lymphatic drainage from a tumor can be removed by limited surgery and examined to determine whether more extensive lymph node dissection was necessary. Sentinel lymph node biopsy carries lower morbidity and cost than a complete lymph node dissection. In this study, the researchers looked at the feasibility of SLN biopsy in patients with squamous cell carcinoma of the vulva.
MethodA total of 59 patients with primary early-stage vulvar cancer underwent SLN biopsy. The researchers then performed radical excision of the primary tumor with inguinofemoral lymphadenectomy to verify their results.
- SLN biopsy showed metastatic disease in 20 patients
- In the 39 other patients, no false-negative SLN were found.