TJ Smith, LM Ryan, HO Douglass et al
Abramson Cancer Center of the University of Pennsylvania
Last Modified: November 1, 2001
Reviewers: Kenneth Blank, MD
Source: International Journal of Radiation Oncology, Biology and Physics September 1, 1998
Radiation doses were 40Gray for patients receiving surgery and 60Gy if no surgery. Chemotherapy consisted of one or two cycles of bolus mitomycin and continuousinfusion 5-flourouracil (one cycle for surgical patients and two for all others). Sixty patients were randomized to the radiation alone arm and fifty-nine to thechemotherapy+radiotherapy arm. The two treatment arms were well balanced with respect to patient characteristics such as nodal disease, performance status, sex andweight loss. Approximately one-third of patients on both arms received surgery following four weeks of treatment.