Paulo M. Hoff, Vicente Valero, Aman U Buzdar, et al.
Abramson Cancer Center of the University of Pennsylvania
Last Modified: November 1, 2001
Reviewers: Li Liu, MD
Source: Cancer Volume 88, 2054-2060 (May) 2000
Locally advanced breast cancers (LABC) are defined as tumors that measure more than 5 cm, tumors that extend to the chest wall or skin, and tumors with fixed ipsilateral axillary nodes or ipsilateral internal mammary nodes. A multimodality approach has been the treatment of choice for the patients with LABC. However, for elderly patients or patients with severe comorbid conditions, aggressive treatments can be difficult to tolerate. In this study, the researchers evaluated the use of tamoxifen in conjunction with locoregional therapies for patients with LABC who were age > 75 years or who were younger but in poor medical condition.
A total of 47 patients, ages 48 to 86 years, were treated with neoadjuvant tamoxifen followed by surgery and radiotherapy. Adjuvant tamoxifen was given for 5 years or until disease recurrence when feasible.
Neoadjuvant tamoxifen was well tolerated in elderly or frail patients with locally advanced breast carcinoma. Such treatment was proven to be effective with a reasonable response rate and good overall survival for patients with estrogen receptor positive tumors. A larger randomized study is warranted.
Jul 22, 2010 - In patients lacking an HLA-identical donor for stem-cell transplantation, gene therapy may be effective in treating X-linked severe combined immunodeficiency, though the treatment carries a risk of acute leukemia, according to research published in the July 22 issue of the New England Journal of Medicine.
Jul 22, 2010